Detailed information of TA system TA141885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 72532..73189
• Replicon: plasmid pM-3471_DHA
• Accession: NZ_CP045459
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain M-3471

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: GER29_RS22685
• Protein ID: WP_000270043.1
• Coordinates: 72532..72882 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GER29_RS22690
• Protein ID: WP_000124640.1
• Coordinates: 72887..73189 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GER29_RS22635	67843..68022	+	180	Protein_84	helix-turn-helix transcriptional regulator	-
GER29_RS22640	68087..68791	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
GER29_RS22645	69006..69503	-	498	WP_000062185.1	hypothetical protein	-
GER29_RS22650	69506..69994	-	489	WP_001273096.1	DUF1643 domain-containing protein	-
GER29_RS22655	70091..70426	+	336	WP_000683476.1	hypothetical protein	-
GER29_RS22660	70441..70911	-	471	WP_001281821.1	hypothetical protein	-
GER29_RS22665	70904..71275	-	372	WP_000516916.1	hypothetical protein	-
GER29_RS22670	71286..71480	-	195	WP_000343597.1	hypothetical protein	-
GER29_RS22680	71821..72369	-	549	WP_001061574.1	transcriptional regulator	-
GER29_RS22685	72532..72882	+	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GER29_RS22690	72887..73189	+	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
GER29_RS22695	73216..73509	-	294	WP_001239997.1	chromosome segregation protein ParM	-
GER29_RS22700	73597..73869	-	273	WP_001043047.1	HU family DNA-binding protein	-
GER29_RS22705	73927..74454	-	528	WP_001236377.1	thermonuclease family protein	-
GER29_RS22715	74685..75542	-	858	WP_001167032.1	hypothetical protein	-
GER29_RS22720	75529..75759	-	231	WP_000972663.1	hypothetical protein	-
GER29_RS22725	75759..76277	-	519	WP_000210756.1	nitrite reductase	-
GER29_RS22730	76274..76720	-	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
GER29_RS22735	76720..77079	-	360	WP_000422768.1	hypothetical protein	-
GER29_RS22740	77136..77564	-	429	WP_000591074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..89619	89619

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T141885 WP_000270043.1 NZ_CP045459:72532-72882 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T141885 NZ_CP060156:c1144611-1144357 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>AT141885 WP_000124640.1 NZ_CP045459:72887-73189 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>AT141885 NZ_CP060156:c1144855-1144613 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9