141858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 250636..251177 Replicon chromosome
Accession NZ_CP045457
Organism Escherichia coli strain ET12567

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag ECET_RS01155 Protein ID WP_000615983.1
Coordinates 250636..250914 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag ECET_RS01160 Protein ID WP_000729703.1
Coordinates 250917..251177 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECET_RS01140 248218..248796 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
ECET_RS01145 249002..249769 + 768 WP_000333380.1 class II glutamine amidotransferase -
ECET_RS01150 249740..250480 - 741 WP_001225679.1 murein L,D-transpeptidase -
ECET_RS01155 250636..250914 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ECET_RS01160 250917..251177 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ECET_RS01165 251387..252136 + 750 WP_133412475.1 C40 family peptidase -
ECET_RS01170 252312..252809 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
ECET_RS01175 253033..254772 - 1740 WP_001334802.1 flagellar biosynthesis protein FlhA -
ECET_RS01180 254717..255502 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T141858 WP_000615983.1 NZ_CP045457:c250914-250636 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T141858 NZ_CP060122:c4679332-4679042 [Sphingobium yanoikuyae]
GTGAGACGGCTGCTTTTTACGCCGGCGGCGCAGGCCGACCTGTCCGACATCTGGGATTATAGCGCGGCGACCTGGGGCGT
GGATCAGGCTGATCTCTATATCGATGCGATCCGCGATGTCTGTCTGGCATTGGCGGATGGGCGGCGGCCGGGGCTGCCGG
TCGATGTGCGGGCCGGTTATCGCAAGGCGCCAGCGGGATCGCACATGATCTATTATCGCGACGGTGGCGATCATCTGGCC
ATTGTCCGTGTCCTGCATGGGCGACAGGATACGGGGCGGTATTTGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT141858 WP_000729703.1 NZ_CP045457:c251177-250917 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT141858 NZ_CP060122:c4679582-4679346 [Sphingobium yanoikuyae]
ATGGCGCGCAACACATCGGTGACGATCGGCGATCATTTTACCCGCTTCATCAGCGATCAGGTGCAGACCGGTCGCTATGG
ATCGGCGAGCGATGTCGTGCGGGCGGGGCTGCGTCTGCTGGAAGAGCATGAGGCGCAGGTGCAGGCGTTGCAGGCGGCGC
TGATCGCCGGGGAGGAGTCGGGCGCGGCGACGCCGTTCGATTTCGAGGCGTTCAAGGCGGCCAAGCGCGGCTGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References