Detailed information of TA system TA141855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2923431..2924109
• Replicon: chromosome
• Accession: NZ_CP045456
• Organism: Brevundimonas sp. Bb-A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0P0DEC1
• Locus tag: BSP_RS14410
• Protein ID: WP_054766417.1
• Coordinates: 2923431..2923787 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BSP_RS14415
• Protein ID: WP_054766418.1
• Coordinates: 2923789..2924109 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSP_RS14385	2918587..2918831	+	245	Protein_2834	DUF4160 domain-containing protein	-
BSP_RS14390	2918812..2919069	+	258	WP_152950783.1	DUF2442 domain-containing protein	-
BSP_RS14395	2919169..2920560	+	1392	WP_152950784.1	cytochrome P450	-
BSP_RS14400	2920720..2921739	+	1020	WP_152950785.1	glycosyltransferase family 4 protein	-
BSP_RS14405	2921807..2923372	+	1566	WP_152950786.1	alkaline phosphatase D family protein	-
BSP_RS14410	2923431..2923787	+	357	WP_054766417.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSP_RS14415	2923789..2924109	+	321	WP_054766418.1	XRE family transcriptional regulator	Antitoxin
BSP_RS14420	2924159..2924980	-	822	WP_054766419.1	YmdB family metallophosphoesterase	-
BSP_RS14425	2924977..2925411	-	435	WP_054766420.1	PIN domain-containing protein	-
BSP_RS14430	2925411..2925653	-	243	WP_054766421.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
BSP_RS14435	2925700..2926242	-	543	WP_054766422.1	5-formyltetrahydrofolate cyclo-ligase	-
BSP_RS14445	2926524..2926841	-	318	WP_054766423.1	cell division protein ZapA	-
BSP_RS14450	2926841..2927137	-	297	WP_054766424.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13150.01 Da
• Isoelectric Point: 6.8819

>T141855 WP_054766417.1 NZ_CP045456:2923431-2923787 [Brevundimonas sp. Bb-A]
MPWAVSNHDEFDPEFDALPVEVQDELLAMTALLEVYGPRLGRPHADTLAGSRHANMKELRFKAADGVWRVAFAFDPERQA
ILLVAGDKAGAAQKRFYKGLIAKADSRFTSHLRALKET

Nucleotide

• Length: 357 bp

>T141855 NZ_CP060122:4319298-4319576 [Sphingobium yanoikuyae]
ATGACCCTGCCGGTCGTCTGGGATGACGAGGCCGAAACGGCCCTCCTGACCATCCTCGACTATATCGGCCCGCGCAACAA
AGTGGCGGCCGAACGCCTCTATGCCGCCATCCGGCACACTGCCGACAATCTGCCCAACCATCCCTATGCGCATCGTCCCG
GCCGCATGTCCGGCACGCGCGAAGCCGTGGTTCACCCCAATTATATCCTCATCTACCGCGTCGCGATCGAGGCGATCGAG
ATATTGACGCTCGTCCACGCCCGCCAGCAATATCCCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11662.48 Da
• Isoelectric Point: 7.2072

>AT141855 WP_054766418.1 NZ_CP045456:2923789-2924109 [Brevundimonas sp. Bb-A]
MGRTREEIMAALPEARRTRIDARAAELVGEVEGLKALRELAERSQEQIAQALGVKQPSVLKMERQADLYLSTLRRFVEAA
GGTLELRVELPGKGVLHLTGMGDISH

Nucleotide

• Length: 321 bp

>AT141855 NZ_CP060122:4319131-4319301 [Sphingobium yanoikuyae]
ATGACCAAGCTCACCCCAATCGAGTCCGAGTTCGCGACGACCGAGGATGCGGAAGCCCATGACGCATGGGTCCGCGCCAA
GGTGGAACGCGCACTGGCCTCCACCAAGCCGCGCATCCCGCATGACGCAGTCATGGCCAAGGCGCAGGCCGTTCTCGACA
AATATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0P0DEC1