Detailed information of TA system TA141830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3558370..3559045
• Replicon: chromosome
• Accession: NZ_CP045450
• Organism: Enterobacter hormaechei strain 14280161202

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A837FDC1
• Locus tag: GEA58_RS16835
• Protein ID: WP_015571638.1
• Coordinates: 3558370..3558669 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GEA58_RS16840
• Protein ID: WP_203453051.1
• Coordinates: 3558680..3559045 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEA58_RS16825	3554747..3556939	+	2193	WP_203453050.1	type I secretion system permease/ATPase	-
GEA58_RS16830	3556959..3558119	+	1161	WP_085929677.1	HlyD family efflux transporter periplasmic adaptor subunit	-
GEA58_RS16835	3558370..3558669	+	300	WP_015571638.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GEA58_RS16840	3558680..3559045	+	366	WP_203453051.1	HigA family addiction module antidote protein	Antitoxin
GEA58_RS16845	3559072..3560253	-	1182	WP_017382758.1	PLP-dependent aminotransferase family protein	-
GEA58_RS16850	3560274..3561161	-	888	WP_203453052.1	LysR family transcriptional regulator	-
GEA58_RS16855	3561259..3561861	+	603	WP_203453053.1	short chain dehydrogenase	-
GEA58_RS16860	3561858..3562589	-	732	WP_017382760.1	methyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11624.29 Da
• Isoelectric Point: 9.6776

>T141830 WP_015571638.1 NZ_CP045450:3558370-3558669 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Nucleotide

• Length: 300 bp

>T141830 NZ_CP060121:c414017-413475 [Escherichia coli BL21]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13715.77 Da
• Isoelectric Point: 9.5936

>AT141830 WP_203453051.1 NZ_CP045450:3558680-3559045 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKPGKPDVTLHGNSA

Nucleotide

• Length: 366 bp

>AT141830 NZ_CP060121:c414312-414001 [Escherichia coli BL21]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A837FDC1