Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2912534..2913194 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q4X0
Locus tag GEA58_RS13940 Protein ID WP_017383312.1
Coordinates 2912841..2913194 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag GEA58_RS13935 Protein ID WP_017383313.1
Coordinates 2912534..2912836 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS13920 2908708..2910033 + 1326 WP_047063111.1 SidA/IucD/PvdA family monooxygenase -
GEA58_RS13925 2910060..2912249 + 2190 WP_032654151.1 TonB-dependent siderophore receptor -
GEA58_RS13935 2912534..2912836 - 303 WP_017383313.1 helix-turn-helix transcriptional regulator Antitoxin
GEA58_RS13940 2912841..2913194 - 354 WP_017383312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEA58_RS13945 2913385..2914335 - 951 WP_017383311.1 HTH-type transcriptional regulator Cbl -
GEA58_RS13950 2914432..2915349 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
GEA58_RS13960 2915880..2916812 - 933 WP_203452988.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13537.37 Da        Isoelectric Point: 9.9538

>T141828 WP_017383312.1 NZ_CP045450:c2913194-2912841 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

>T141828 NZ_CP060121:c250813-250535 [Escherichia coli BL21]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAA
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT141828 WP_017383313.1 NZ_CP045450:c2912836-2912534 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT141828 NZ_CP060121:c251076-250816 [Escherichia coli BL21]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q4X0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References