Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2562695..2563212 Replicon chromosome
Accession NZ_CP045435
Organism Staphylococcus aureus strain 08-028

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SA08028_RS13040 Protein ID WP_000113262.1
Coordinates 2562695..2562961 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SA08028_RS13045 Protein ID WP_000584499.1
Coordinates 2562961..2563212 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA08028_RS13015 2558120..2558647 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
SA08028_RS13020 2558891..2559715 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SA08028_RS13025 2559932..2560114 - 183 WP_000230294.1 hypothetical protein -
SA08028_RS13030 2560198..2560665 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SA08028_RS13035 2560851..2562401 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SA08028_RS13040 2562695..2562961 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SA08028_RS13045 2562961..2563212 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SA08028_RS13050 2563377..2563478 - 102 Protein_2532 hypothetical protein -
SA08028_RS13055 2563485..2564084 - 600 WP_000162810.1 DsbA family protein -
SA08028_RS13060 2564103..2564465 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SA08028_RS13065 2564720..2565970 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
SA08028_RS13070 2566067..2566798 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
SA08028_RS13075 2566795..2567514 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T141808 WP_000113262.1 NZ_CP045435:c2562961-2562695 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T141808 NZ_CP060112:328402-328659 [Fusobacterium hwasookii]
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGCTACAAGAGAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT141808 WP_000584499.1 NZ_CP045435:c2563212-2562961 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT141808 NZ_CP060112:328145-328402 [Fusobacterium hwasookii]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References