Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2156637..2157060 | Replicon | chromosome |
| Accession | NZ_CP045435 | ||
| Organism | Staphylococcus aureus strain 08-028 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5S9I4Y6 |
| Locus tag | SA08028_RS10885 | Protein ID | WP_001065091.1 |
| Coordinates | 2156809..2157060 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0E0VQM8 |
| Locus tag | SA08028_RS10880 | Protein ID | WP_000028422.1 |
| Coordinates | 2156637..2156819 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SA08028_RS10835 | 2153115..2153582 | - | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
| SA08028_RS10840 | 2153710..2154054 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| SA08028_RS10845 | 2154070..2154522 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| SA08028_RS10850 | 2154637..2155107 | - | 471 | WP_179976074.1 | hypothetical protein | - |
| SA08028_RS10855 | 2155130..2155330 | - | 201 | WP_000265041.1 | DUF1514 family protein | - |
| SA08028_RS10860 | 2155330..2155479 | - | 150 | WP_179976075.1 | transcriptional regulator | - |
| SA08028_RS10865 | 2155476..2155862 | - | 387 | WP_000592207.1 | hypothetical protein | - |
| SA08028_RS10870 | 2155859..2156065 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| SA08028_RS10875 | 2156102..2156644 | - | 543 | WP_000185659.1 | dUTP pyrophosphatase | - |
| SA08028_RS10880 | 2156637..2156819 | - | 183 | WP_000028422.1 | hypothetical protein | Antitoxin |
| SA08028_RS10885 | 2156809..2157060 | - | 252 | WP_001065091.1 | DUF1024 family protein | Toxin |
| SA08028_RS10890 | 2157053..2157220 | - | 168 | WP_001624242.1 | hypothetical protein | - |
| SA08028_RS10895 | 2157232..2157474 | - | 243 | WP_000131366.1 | hypothetical protein | - |
| SA08028_RS10900 | 2157478..2157846 | - | 369 | WP_000101274.1 | hypothetical protein | - |
| SA08028_RS10905 | 2157859..2158263 | - | 405 | WP_000401960.1 | RusA family crossover junction endodeoxyribonuclease | - |
| SA08028_RS10910 | 2158272..2158490 | - | 219 | WP_000338530.1 | hypothetical protein | - |
| SA08028_RS10915 | 2158497..2159381 | - | 885 | WP_000148316.1 | DnaD domain protein | - |
| SA08028_RS10920 | 2159411..2159881 | - | 471 | WP_000934764.1 | single-stranded DNA-binding protein | - |
| SA08028_RS10925 | 2159882..2160499 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| SA08028_RS10930 | 2160580..2161500 | - | 921 | WP_000138472.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak / hlb / groEL | 2129796..2186199 | 56403 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9349.22 Da Isoelectric Point: 3.9473
>T141803 WP_001065091.1 NZ_CP045435:c2157060-2156809 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T141803 NZ_CP060111:2060811-2061143 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAATTTTGCTCGCA
CGGCAGGTTTCAACGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAACGGCAAGCGGCTGGAAAGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTAAGTTAA
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAATTTTGCTCGCA
CGGCAGGTTTCAACGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAACGGCAAGCGGCTGGAAAGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTAAGTTAA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6741.63 Da Isoelectric Point: 4.2658
>AT141803 WP_000028422.1 NZ_CP045435:c2156819-2156637 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
Download Length: 183 bp
>AT141803 NZ_CP060111:2060553-2060810 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGTT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGTT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5S9I4Y6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VQM8 |