Detailed information of TA system TA141800

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2133425..2133732
• Replicon: chromosome
• Accession: NZ_CP045435
• Organism: Staphylococcus aureus strain 08-028

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SA08028_RS10735
• Protein ID: WP_072353918.1
• Coordinates: 2133556..2133732 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2133425..2133564 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA08028_RS10695	2128993..2129172	+	180	WP_000669791.1	hypothetical protein	-
SA08028_RS10700	2129483..2129743	+	261	WP_001791826.1	hypothetical protein	-
SA08028_RS10705	2129796..2130146	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SA08028_RS10710	2130656..2130991	-	336	Protein_2078	SH3 domain-containing protein	-
SA08028_RS10715	2131642..2132133	-	492	WP_000920038.1	staphylokinase	-
SA08028_RS10720	2132323..2133078	-	756	WP_031763770.1	CHAP domain-containing protein	-
SA08028_RS10725	2133090..2133344	-	255	WP_000611512.1	phage holin	-
SA08028_RS10730	2133396..2133503	+	108	WP_031762631.1	hypothetical protein	-
-	2133425..2133564	+	140	NuclAT_0	-	Antitoxin
-	2133425..2133564	+	140	NuclAT_0	-	Antitoxin
-	2133425..2133564	+	140	NuclAT_0	-	Antitoxin
-	2133425..2133564	+	140	NuclAT_0	-	Antitoxin
SA08028_RS10735	2133556..2133732	-	177	WP_072353918.1	putative holin-like toxin	Toxin
SA08028_RS10740	2133875..2134249	-	375	WP_000340977.1	hypothetical protein	-
SA08028_RS10745	2134305..2134592	-	288	WP_001262620.1	hypothetical protein	-
SA08028_RS10750	2134638..2134790	-	153	WP_001000058.1	hypothetical protein	-
SA08028_RS10755	2134783..2138566	-	3784	Protein_2087	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2129796..2186199	56403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T141800 WP_072353918.1 NZ_CP045435:c2133732-2133556 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T141800 NZ_CP060111:891786-892196 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGTATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCATGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATTATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
ACAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT141800 NZ_CP045435:2133425-2133564 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin