Detailed information of TA system TA141793

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1650548..1651127
• Replicon: chromosome
• Accession: NZ_CP045435
• Organism: Staphylococcus aureus strain 08-028

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SA08028_RS08150
• Protein ID: WP_001025401.1
• Coordinates: 1650882..1651127 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1650548..1650913 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA08028_RS08110	1647292..1647849	-	558	WP_000645042.1	DUF2815 family protein	-
SA08028_RS08115	1647875..1649041	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SA08028_RS08120	1649038..1649400	-	363	WP_000985984.1	hypothetical protein	-
SA08028_RS08125	1649415..1649738	-	324	WP_000175001.1	hypothetical protein	-
SA08028_RS08130	1649817..1649978	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SA08028_RS08135	1649991..1650253	-	263	Protein_1602	helix-turn-helix domain-containing protein	-
SA08028_RS08140	1650278..1650493	-	216	WP_001097552.1	hypothetical protein	-
SA08028_RS08145	1650548..1650913	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SA08028_RS08150	1650882..1651127	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SA08028_RS08155	1651183..1651392	+	210	WP_000642492.1	hypothetical protein	-
SA08028_RS08160	1651382..1651525	-	144	WP_000939498.1	hypothetical protein	-
SA08028_RS08165	1651554..1652330	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SA08028_RS08170	1652344..1652580	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SA08028_RS08175	1652732..1653046	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SA08028_RS08180	1653059..1653520	+	462	WP_000525004.1	hypothetical protein	-
SA08028_RS08185	1653538..1654122	+	585	WP_000825948.1	hypothetical protein	-
SA08028_RS08190	1654352..1654498	+	147	WP_001013104.1	hypothetical protein	-
SA08028_RS08195	1654495..1655109	-	615	Protein_1614	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1610933..1679022	68089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T141793 WP_001025401.1 NZ_CP045435:c1651127-1650882 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T141793 NZ_CP060092:c995327-995025 [Teredinibacter purpureus]
ATGAGCGCATTTACTTTAACACGACGTGCTAAAACTGATTTGAAATCTATAGCTAAATTTACTGAAAAGCGCTGGGGACG
AGAGCAACGCTACATTTACATTAAGCAATTTGATGATACATTTCATGTGCTTTCTAATACCCCCGAAATAGGCAATAACT
GTAACCATATAAAAGAAAATTACCAAAGATTTCCTCAGGGTAGTCATATAATTTTTTATCGCATAGCGACCCAAGGCAGC
ATTCAAATTATTCGTATTCTCCACAAAAATATGGACGTACTCTCAAAATTTGGCGGCTCATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT141793 NZ_CP045435:1650548-1650913 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin