Detailed information of TA system TA141789

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 386802..387140
• Replicon: chromosome
• Accession: NZ_CP045435
• Organism: Staphylococcus aureus strain 08-028

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SA08028_RS01845
• Protein ID: WP_011447039.1
• Coordinates: 386802..386978 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	386966..387140 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA08028_RS01825	381967..385750	+	3784	Protein_362	hypothetical protein	-
SA08028_RS01830	385743..385895	+	153	WP_058343640.1	hypothetical protein	-
SA08028_RS01835	385941..386228	+	288	WP_031763773.1	hypothetical protein	-
SA08028_RS01840	386284..386658	+	375	WP_000340974.1	hypothetical protein	-
SA08028_RS01845	386802..386978	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	386966..387140	-	175	-	-	Antitoxin
SA08028_RS01855	387190..387444	+	255	WP_000611512.1	phage holin	-
SA08028_RS01860	387456..388210	+	755	Protein_369	CHAP domain-containing protein	-
SA08028_RS01865	389301..390128	-	828	WP_075111624.1	alpha/beta hydrolase	-
SA08028_RS01870	390201..391400	-	1200	WP_000286483.1	NADH-dependent flavin oxidoreductase	-
SA08028_RS01875	391496..391588	+	93	WP_001801779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	347397..391400	44003

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T141789 WP_011447039.1 NZ_CP045435:386802-386978 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T141789 NZ_CP060088:2027044-2027340 [Vibrio parahaemolyticus]
ATGCAAAAGAATAAATACAAACTAAGTAAATTAGCTCAGGCTCATTTATTAAAAATCAAAAACTACACCGTTAATAACTT
TTCAGAGATGCAGTGGCGCAATTACAAAGATACGTTACTAACTGGGTTTCAGATGCTTGCTGGCAATCCGGAAGTCGGTC
GAAGTTGCGATGACATTTACCCAAACGGGTTTCACTTCCCTGTTGGTAAGCACACAGCTTACTTTACAAAAGAAGACGGC
TTCATTTTGGTTGTAGCTGTACTCGGTCAGTCACAATTACCGCAAAACCACTTATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT141789 NZ_CP045435:c387140-386966 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin