Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 119..776 | Replicon | plasmid pTHAF12_c |
Accession | NZ_CP045402 | ||
Organism | Halomonas sp. THAF12 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | FIU88_RS18945 | Protein ID | WP_152480276.1 |
Coordinates | 432..776 (-) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | FIU88_RS18940 | Protein ID | WP_152480275.1 |
Coordinates | 119..421 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FIU88_RS18940 | 119..421 | - | 303 | WP_152480275.1 | helix-turn-helix domain-containing protein | Antitoxin |
FIU88_RS18945 | 432..776 | - | 345 | WP_152480276.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FIU88_RS18950 | 999..1271 | - | 273 | WP_152480277.1 | hypothetical protein | - |
FIU88_RS18955 | 1268..2209 | - | 942 | WP_152480278.1 | integrase domain-containing protein | - |
FIU88_RS18960 | 3895..4827 | + | 933 | WP_172977769.1 | replication initiation protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..23068 | 23068 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13223.91 Da Isoelectric Point: 4.7453
>T141767 WP_152480276.1 NZ_CP045402:c776-432 [Halomonas sp. THAF12]
MWSIEQTETFEDWYYSLDDVDRENVLASMLLLQEKGPMLSRPHADTVNGSRYPNMKELRIQSQGKPFRAFFAFDPNRTGL
LLCAGDKGGNEKRFYDEMIPIADREYAAHLESLK
MWSIEQTETFEDWYYSLDDVDRENVLASMLLLQEKGPMLSRPHADTVNGSRYPNMKELRIQSQGKPFRAFFAFDPNRTGL
LLCAGDKGGNEKRFYDEMIPIADREYAAHLESLK
Download Length: 345 bp
>T141767 NZ_CP060083:c4083213-4082815 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 10995.77 Da Isoelectric Point: 7.2056
>AT141767 WP_152480275.1 NZ_CP045402:c421-119 [Halomonas sp. THAF12]
MARKLEQLLANEKPEVVAAAKAKADEMLLELRLSEVRRLVEMTQAQMADAMGVRQPTVAGMEKGGQDLRLSSIKRYVEAV
GGRVRLDVELPDGSHHGFPV
MARKLEQLLANEKPEVVAAAKAKADEMLLELRLSEVRRLVEMTQAQMADAMGVRQPTVAGMEKGGQDLRLSSIKRYVEAV
GGRVRLDVELPDGSHHGFPV
Download Length: 303 bp
>AT141767 NZ_CP060083:c4083509-4083216 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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