Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 119..776 Replicon plasmid pTHAF12_c
Accession NZ_CP045402
Organism Halomonas sp. THAF12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FIU88_RS18945 Protein ID WP_152480276.1
Coordinates 432..776 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FIU88_RS18940 Protein ID WP_152480275.1
Coordinates 119..421 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU88_RS18940 119..421 - 303 WP_152480275.1 helix-turn-helix domain-containing protein Antitoxin
FIU88_RS18945 432..776 - 345 WP_152480276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU88_RS18950 999..1271 - 273 WP_152480277.1 hypothetical protein -
FIU88_RS18955 1268..2209 - 942 WP_152480278.1 integrase domain-containing protein -
FIU88_RS18960 3895..4827 + 933 WP_172977769.1 replication initiation protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23068 23068


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(18-89)


Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 13223.91 Da        Isoelectric Point: 4.7453

>T141767 WP_152480276.1 NZ_CP045402:c776-432 [Halomonas sp. THAF12]
MWSIEQTETFEDWYYSLDDVDRENVLASMLLLQEKGPMLSRPHADTVNGSRYPNMKELRIQSQGKPFRAFFAFDPNRTGL
LLCAGDKGGNEKRFYDEMIPIADREYAAHLESLK

Download         Length: 345 bp

>T141767 NZ_CP060083:c4083213-4082815 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10995.77 Da        Isoelectric Point: 7.2056

>AT141767 WP_152480275.1 NZ_CP045402:c421-119 [Halomonas sp. THAF12]
MARKLEQLLANEKPEVVAAAKAKADEMLLELRLSEVRRLVEMTQAQMADAMGVRQPTVAGMEKGGQDLRLSSIKRYVEAV
GGRVRLDVELPDGSHHGFPV

Download         Length: 303 bp

>AT141767 NZ_CP060083:c4083509-4083216 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References