Detailed information of TA system TA141753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 2404719..2405310
• Replicon: chromosome
• Accession: NZ_CP045367
• Organism: Marinobacter sp. THAF39

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FIU96_RS11120
• Protein ID: WP_152439646.1
• Coordinates: 2404999..2405310 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FIU96_RS11115
• Protein ID: WP_152438353.1
• Coordinates: 2404719..2405006 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU96_RS11075	2401113..2401730	-	618	WP_152438345.1	class I SAM-dependent methyltransferase	-
FIU96_RS11080	2401779..2402201	-	423	WP_152438346.1	hypothetical protein	-
FIU96_RS11085	2402283..2402708	-	426	WP_152438347.1	N-acetyltransferase	-
FIU96_RS11090	2402778..2403224	-	447	WP_152438348.1	NUDIX domain-containing protein	-
FIU96_RS11095	2403350..2403544	+	195	WP_152438349.1	type II toxin-antitoxin system VapB family antitoxin	-
FIU96_RS11100	2403541..2403942	+	402	WP_152438350.1	PIN domain nuclease	-
FIU96_RS11105	2404074..2404319	+	246	WP_152438351.1	type II toxin-antitoxin system CcdA family antitoxin	-
FIU96_RS11110	2404319..2404636	+	318	WP_152438352.1	CcdB family protein	-
FIU96_RS11115	2404719..2405006	-	288	WP_152438353.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FIU96_RS11120	2404999..2405310	-	312	WP_152439646.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU96_RS11125	2405461..2406786	-	1326	WP_152438354.1	group II intron reverse transcriptase/maturase	-
FIU96_RS11130	2407299..2407631	-	333	WP_152438355.1	hypothetical protein	-
FIU96_RS11135	2407708..2408160	-	453	WP_152438356.1	hypothetical protein	-
FIU96_RS11140	2408313..2409116	-	804	WP_152438357.1	IS21-like element helper ATPase IstB	-
FIU96_RS11145	2409113..2410297	-	1185	WP_152438358.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2401779..2427685	25906
	-	flank	IS/Tn	-	-	2408313..2409116	803
	-	inside	Integron	-	-	2404319..2429171	24852

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (33-93)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11591.31 Da
• Isoelectric Point: 10.0163

>T141753 WP_152439646.1 NZ_CP045367:c2405310-2404999 [Marinobacter sp. THAF39]
MLFIETSTFTRLLPNYLTDEEYRGLQTYLLQKPDAGDLIKGSGGVRKVRWAPAGSGKSGGIRAIYYWKKSDHEIWMLTLY
SKSERASIPGHTLKQIAEAIKNG

Nucleotide

• Length: 312 bp

>T141753 NZ_CP060083:710985-711281 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10648.32 Da
• Isoelectric Point: 10.0887

>AT141753 WP_152438353.1 NZ_CP045367:c2405006-2404719 [Marinobacter sp. THAF39]
MGDRNLGAEILDGINEIKQFKKGKLALRTHELSEPSPPKVIRLKLHMSQSAFAGLMGVSIRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFSQLH

Nucleotide

• Length: 288 bp

>AT141753 NZ_CP060083:711283-711678 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA