Detailed information of TA system TA141738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 667636..668243
• Replicon: chromosome
• Accession: NZ_CP045354
• Organism: Labrenzia sp. THAF82

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: FIV00_RS03275
• Protein ID: WP_152504091.1
• Coordinates: 667636..667920 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FIV00_RS03280
• Protein ID: WP_152499455.1
• Coordinates: 667938..668243 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV00_RS30060	662914..663036	+	123	WP_209006796.1	hypothetical protein	-
FIV00_RS03240	663033..663848	+	816	WP_152499449.1	AAA family ATPase	-
FIV00_RS03245	663906..664220	+	315	WP_152499450.1	hypothetical protein	-
FIV00_RS03250	664649..664933	+	285	WP_152499451.1	DUF1467 family protein	-
FIV00_RS03255	665043..665609	+	567	WP_152499452.1	recombinase family protein	-
FIV00_RS03260	666112..666627	+	516	WP_152499453.1	hypothetical protein	-
FIV00_RS03265	666709..667008	+	300	WP_152499454.1	transposase	-
FIV00_RS03270	667174..667359	+	186	WP_209006797.1	helix-turn-helix domain-containing protein	-
FIV00_RS03275	667636..667920	+	285	WP_152504091.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIV00_RS03280	667938..668243	+	306	WP_152499455.1	HigA family addiction module antidote protein	Antitoxin
FIV00_RS03285	669102..669236	-	135	Protein_649	transposase	-
FIV00_RS03290	669344..669658	+	315	WP_209006798.1	helix-turn-helix transcriptional regulator	-
FIV00_RS03300	670101..670826	-	726	WP_152499456.1	hypothetical protein	-
FIV00_RS03310	672346..672657	-	312	WP_152504094.1	type IV secretory system conjugative DNA transfer family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	636453..678093	41640

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-66)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10856.21 Da
• Isoelectric Point: 7.9893

>T141738 WP_152504091.1 NZ_CP045354:667636-667920 [Labrenzia sp. THAF82]
MILNYADKKTEKFAKGQFVKAFQGFEDQAEKRLAILNAATSLNDLRSLPSNRLESLRGDRAGQYSIRINQQYRICFKWPE
DQQGASDVEIVDYH

Nucleotide

• Length: 285 bp

>T141738 NZ_CP060075:c2543526-2543044 [Escherichia coli]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11179.76 Da
• Isoelectric Point: 4.7628

>AT141738 WP_152499455.1 NZ_CP045354:667938-668243 [Labrenzia sp. THAF82]
MFERTVHPGTILKDELLELGISPTELARQIDVPANRISMILNGKRAISGDTALRLGHWFGNEPQFWLNLQNQFDLAAAEK
ETGGVIDALPTKDSLPQQSLL

Nucleotide

• Length: 306 bp

>AT141738 NZ_CP060075:c2543780-2543514 [Escherichia coli]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA