Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2861181..2861814 Replicon chromosome
Accession NZ_CP045350
Organism Vibrio aquimaris strain THAF100

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FIV01_RS13245 Protein ID WP_152431382.1
Coordinates 2861482..2861814 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FIV01_RS13240 Protein ID WP_114787371.1
Coordinates 2861181..2861495 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV01_RS13225 2856752..2857489 - 738 WP_152431379.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
FIV01_RS13230 2857502..2859967 - 2466 WP_152431380.1 ribonuclease R -
FIV01_RS13235 2860193..2860906 - 714 WP_152431381.1 hypothetical protein -
FIV01_RS13240 2861181..2861495 - 315 WP_114787371.1 transcriptional regulator Antitoxin
FIV01_RS13245 2861482..2861814 - 333 WP_152431382.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIV01_RS13250 2861963..2862601 - 639 WP_114787373.1 sel1 repeat family protein -
FIV01_RS13255 2862863..2864179 - 1317 WP_152431383.1 adenylosuccinate synthase -
FIV01_RS13260 2864313..2865254 - 942 WP_152431384.1 isoaspartyl peptidase/L-asparaginase -
FIV01_RS13265 2865363..2865905 - 543 WP_152431385.1 peptidylprolyl isomerase -
FIV01_RS13270 2866000..2866194 - 195 WP_152431386.1 YheV family putative metal-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12874.70 Da        Isoelectric Point: 10.1192

>T141736 WP_152431382.1 NZ_CP045350:c2861814-2861482 [Vibrio aquimaris]
MKSVFVESSIFEKYRSQYLSDEEFRLFQAEIMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEQRRFYLLT
IYGKNEVSDLTAEQKKQLKAFMEAWRNEQS

Download         Length: 333 bp

>T141736 NZ_CP060075:2107502-2107605 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCTTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11790.26 Da        Isoelectric Point: 5.1489

>AT141736 WP_114787371.1 NZ_CP045350:c2861495-2861181 [Vibrio aquimaris]
MNNRDLFAELSSALSEAKQHSEGKLTLKTYQVDDINELNISPEEILSLREQFNMSRGVFARLLHTSSRTLESWEQGRSAP
NGQAVTLLKLVQRYPETLSQIAEL

Download         Length: 315 bp

>AT141736 NZ_CP060075:c2107643-2107372 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAAGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References