Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 2411835..2412426 | Replicon | chromosome |
| Accession | NZ_CP045324 | ||
| Organism | Marinobacter sp. THAF197a | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | FIV08_RS11180 | Protein ID | WP_152439646.1 |
| Coordinates | 2412115..2412426 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FIV08_RS11175 | Protein ID | WP_152438353.1 |
| Coordinates | 2411835..2412122 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FIV08_RS11135 | 2408229..2408846 | - | 618 | WP_152438345.1 | class I SAM-dependent methyltransferase | - |
| FIV08_RS11140 | 2408895..2409317 | - | 423 | WP_152438346.1 | hypothetical protein | - |
| FIV08_RS11145 | 2409399..2409824 | - | 426 | WP_152438347.1 | N-acetyltransferase | - |
| FIV08_RS11150 | 2409894..2410340 | - | 447 | WP_152438348.1 | NUDIX domain-containing protein | - |
| FIV08_RS11155 | 2410466..2410660 | + | 195 | WP_152438349.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FIV08_RS11160 | 2410657..2411058 | + | 402 | WP_152438350.1 | PIN domain nuclease | - |
| FIV08_RS11165 | 2411190..2411435 | + | 246 | WP_152438351.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| FIV08_RS11170 | 2411435..2411752 | + | 318 | WP_152438352.1 | CcdB family protein | - |
| FIV08_RS11175 | 2411835..2412122 | - | 288 | WP_152438353.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| FIV08_RS11180 | 2412115..2412426 | - | 312 | WP_152439646.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FIV08_RS11185 | 2412577..2413902 | - | 1326 | WP_152438354.1 | group II intron reverse transcriptase/maturase | - |
| FIV08_RS11190 | 2414415..2414747 | - | 333 | WP_152438355.1 | hypothetical protein | - |
| FIV08_RS11195 | 2414824..2415276 | - | 453 | WP_152438356.1 | hypothetical protein | - |
| FIV08_RS11200 | 2415429..2416232 | - | 804 | WP_152438357.1 | IS21-like element helper ATPase IstB | - |
| FIV08_RS11205 | 2416229..2417413 | - | 1185 | WP_152438358.1 | IS21 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2408229..2432055 | 23826 | |
| - | flank | IS/Tn | - | - | 2415429..2416232 | 803 | |
| - | inside | Integron | - | - | 2411435..2436287 | 24852 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11591.31 Da Isoelectric Point: 10.0163
>T141713 WP_152439646.1 NZ_CP045324:c2412426-2412115 [Marinobacter sp. THAF197a]
MLFIETSTFTRLLPNYLTDEEYRGLQTYLLQKPDAGDLIKGSGGVRKVRWAPAGSGKSGGIRAIYYWKKSDHEIWMLTLY
SKSERASIPGHTLKQIAEAIKNG
MLFIETSTFTRLLPNYLTDEEYRGLQTYLLQKPDAGDLIKGSGGVRKVRWAPAGSGKSGGIRAIYYWKKSDHEIWMLTLY
SKSERASIPGHTLKQIAEAIKNG
Download Length: 312 bp
>T141713 NZ_CP060073:c610623-610159 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10648.32 Da Isoelectric Point: 10.0887
>AT141713 WP_152438353.1 NZ_CP045324:c2412122-2411835 [Marinobacter sp. THAF197a]
MGDRNLGAEILDGINEIKQFKKGKLALRTHELSEPSPPKVIRLKLHMSQSAFAGLMGVSIRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFSQLH
MGDRNLGAEILDGINEIKQFKKGKLALRTHELSEPSPPKVIRLKLHMSQSAFAGLMGVSIRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFSQLH
Download Length: 288 bp
>AT141713 NZ_CP060073:c610958-610623 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|