Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 96207..96853 Replicon chromosome
Accession NZ_CP045312
Organism Enterobacter hormaechei strain 14102KSN

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GC132_RS00475 Protein ID WP_038415013.1
Coordinates 96503..96853 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GC132_RS00470 Protein ID WP_038415012.1
Coordinates 96207..96506 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC132_RS00445 91675..92259 - 585 WP_038415008.1 type 1 fimbrial protein -
GC132_RS00450 92312..92914 - 603 WP_038415009.1 response regulator transcription factor -
GC132_RS00455 93749..94537 + 789 WP_038415010.1 winged helix-turn-helix domain-containing protein -
GC132_RS00460 94539..95018 + 480 WP_022646606.1 hypothetical protein -
GC132_RS00465 95261..96142 + 882 WP_038415011.1 helix-turn-helix domain-containing protein -
GC132_RS00470 96207..96506 - 300 WP_038415012.1 XRE family transcriptional regulator Antitoxin
GC132_RS00475 96503..96853 - 351 WP_038415013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GC132_RS00480 97121..97373 - 253 Protein_95 DNA-binding protein -
GC132_RS00485 97476..97817 - 342 WP_038415015.1 SymE family type I addiction module toxin -
GC132_RS00490 97943..98134 + 192 WP_038416963.1 toxin-antitoxin system HicB family antitoxin -
GC132_RS00495 98140..98766 - 627 WP_051979808.1 hypothetical protein -
GC132_RS00505 99230..100621 + 1392 WP_023299010.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13521.57 Da        Isoelectric Point: 8.8448

>T141696 WP_038415013.1 NZ_CP045312:c96853-96503 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTHHLTSLEAAK

Download         Length: 351 bp

>T141696 NZ_CP060065:c1840998-1840624 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11057.80 Da        Isoelectric Point: 6.4695

>AT141696 WP_038415012.1 NZ_CP045312:c96506-96207 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVAALMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKQVAFHL

Download         Length: 300 bp

>AT141696 NZ_CP060065:c1841456-1841088 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCCCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References