Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 992512..993329 Replicon chromosome
Accession NZ_CP045291
Organism Delftia tsuruhatensis strain TR1180

Toxin (Protein)


Gene name yhaV Uniprot ID A0A072THA9
Locus tag GCS91_RS04525 Protein ID WP_043790975.1
Coordinates 992512..993003 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A072T676
Locus tag GCS91_RS04530 Protein ID WP_043790977.1
Coordinates 993000..993329 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCS91_RS04495 987639..988136 + 498 WP_154833463.1 cobalamin biosynthesis protein -
GCS91_RS04500 988133..989011 + 879 WP_154833464.1 precorrin-4 C(11)-methyltransferase -
GCS91_RS04505 989008..989805 + 798 WP_154833465.1 precorrin-6A synthase (deacetylating) -
GCS91_RS04510 989869..990198 + 330 WP_013800515.1 DHCW motif cupin fold protein -
GCS91_RS04515 990473..991870 + 1398 WP_017406579.1 chloride channel protein -
GCS91_RS04520 991985..992497 + 513 WP_016448386.1 MgtC/SapB family protein -
GCS91_RS04525 992512..993003 - 492 WP_043790975.1 type II toxin-antitoxin system YhaV family toxin Toxin
GCS91_RS04530 993000..993329 - 330 WP_043790977.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
GCS91_RS04535 993426..995669 - 2244 WP_154833466.1 TonB-dependent receptor -
GCS91_RS04540 995793..996188 - 396 WP_154833467.1 hypothetical protein -
GCS91_RS04545 996216..996878 - 663 WP_154833468.1 pyridoxamine 5'-phosphate oxidase family protein -
GCS91_RS04550 996949..997782 + 834 WP_154833469.1 helix-turn-helix transcriptional regulator -
GCS91_RS04555 997849..998124 + 276 WP_016448378.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18801.33 Da        Isoelectric Point: 9.9304

>T141648 WP_043790975.1 NZ_CP045291:c993003-992512 [Delftia tsuruhatensis]
MSAVPPAPLRIHGWTVFMHPLFLAQLQALSHEVEGLKTKDPGGYTRKNATKRLAAIRKLAFDVIPQDPTRPDYRQGHTLG
EEHKHWFRARFFQQYRLFFRFHAPSKIIVFAWVNDEDTRRAYEGSDDAYRVFRKMLANGHPPGDWDSLLAQAESPPPDSQ
PHA

Download         Length: 492 bp

>T141648 NZ_CP060057:1054758-1055093 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12066.48 Da        Isoelectric Point: 4.1858

>AT141648 WP_043790977.1 NZ_CP045291:c993329-993000 [Delftia tsuruhatensis]
MFSTLEAESTLTDRYQTTIPEAVRRALHLSKRDRIHYTILPGGEVVLSRADSTEDADPVLGQFLGFLAQDMAAHPERLQT
MDARLAQQIQALTEGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT141648 NZ_CP060057:1054510-1054758 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A072THA9

Antitoxin

Source ID Structure
AlphaFold DB A0A072T676

References