Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 7126..7634 Replicon plasmid pTP33
Accession NZ_CP045261
Organism Yersinia pestis strain SCPM-O-B-5942 (I-2638)

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K1H0I1
Locus tag GD372_RS22740 Protein ID WP_016257350.1
Coordinates 7374..7634 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1E7YXI3
Locus tag GD372_RS22735 Protein ID WP_016257351.1
Coordinates 7126..7377 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD372_RS22710 3700..4038 - 339 WP_016257047.1 hypothetical protein -
GD372_RS22715 4035..4253 - 219 WP_016257048.1 ANR family transcriptional regulator -
GD372_RS22720 4475..5422 - 948 WP_016257049.1 replication initiation protein -
GD372_RS22725 5847..6674 + 828 WP_134809573.1 DUF4236 domain-containing protein -
GD372_RS22730 6703..7068 + 366 WP_016257352.1 hypothetical protein -
GD372_RS22735 7126..7377 + 252 WP_016257351.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GD372_RS22740 7374..7634 + 261 WP_016257350.1 Txe/YoeB family addiction module toxin Toxin
GD372_RS22745 7637..8197 + 561 WP_016257349.1 3'-5' exoribonuclease -
GD372_RS22750 8176..8391 - 216 WP_071588212.1 WGR domain-containing protein -
GD372_RS22755 8524..8751 - 228 WP_016257348.1 hypothetical protein -
GD372_RS22760 8748..9371 - 624 WP_016257347.1 ParA family protein -
GD372_RS22765 9991..10293 + 303 WP_016257346.1 phage holin family protein -
GD372_RS22770 10295..10720 + 426 WP_025476582.1 lysozyme -
GD372_RS22775 10717..11238 + 522 WP_016257344.1 DUF2514 domain-containing protein -
GD372_RS22780 11292..12293 + 1002 WP_016257343.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33968 33968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10232.70 Da        Isoelectric Point: 9.5040

>T141579 WP_016257350.1 NZ_CP045261:7374-7634 [Yersinia pestis]
VKLVFSDQSWADYLHWQQTDKSMLKRVNLLIKDIQREPFSGMGKPEPLKHHLSGFWSRRIDSEHRLVYRVTDDSLLIASC
RYHYTG

Download         Length: 261 bp

>T141579 NZ_CP060016:c3119154-3118576 [Mycolicibacterium boenickei]
GTGAAACGCCTCGACCTCGTCGTCGGCTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAACTCACCCTGTCACCGCTGCT
CCCCGGCTGCCCGTTCGTGAACGCGGACGAGATCGCCAAGCGACGCTGGCCCGAGAACCCTGCCCCGCACTCCTACGAGG
CGGCCCTGGTCGCCGCCGAAACGCGGGCCAAACTCATCGAGCTCGGTGAGTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCCAAGCTCGAGCTGATCGACGACGCATGCGCCGCCGGGTACACCGTGATCCTGCACTGCATTCTGATCCCCGAAGA
CCTGGCCGTGCAGCGAGTGCGTCACCGCGTGCAGGCCGGTGGACATGACGTCCCCGAAGCCAAGATCCGCGAACGCTACC
AACGACTTTGGGGTCTCGTCGCGATCGCCGCGATGCACGCGGACTCGGCGACGTTCTACGACAACAGCACTGTCAACGGC
CCGCGCATCGTCGCTCAACTGGCCGGCGGATTCGTCGTCGGATCACCCACGTGGCCGAAATGGACACCCGCGGTGCTGAG
TTCGCGCTGGCCCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9495.74 Da        Isoelectric Point: 4.4488

>AT141579 WP_016257351.1 NZ_CP045261:7126-7377 [Yersinia pestis]
MKTMNYSEARQNFASVMNETIDDRAPILITRQKGMPCVLMSLEEYDSLEETAYLLRSPVNARHLMDSIEQLNNGKGTERD
LAE

Download         Length: 252 bp

>AT141579 NZ_CP060016:c3119581-3119192 [Mycolicibacterium boenickei]
ATGACCGAGACCGCAGACCGGGTGACCCGGTTCGCCGCTGATCTCATGGACAGTGCCGCCGCGGAAGGCGCACGTCAGAG
CCGGTCGGCCAAGCAGCAACTCGACCACTGGGCCCGCGTGGGACGGGCGGTGTCCAGCCAGCACAGCGCGGCACGCCGCA
AGGTGGAGTCCGCTCTGGCGGGCAGTACTCCCCTGCGGGAGTTGACCGCCGAGGAAGGTGCCGTGTTCGACGCCGAGATC
GCCGCTTCCATAGAAGAGAACCTGGCGCGTGCCGACTACGGCAAGATCCTGGCCGGACGCGGCATCACCACCGTGGCGCT
CGACGAGAACGGCGAGATCGTGCAGTACCGCCCCGACGGCACCACCACGGTACTGGCGCACCCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1H0I1

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7YXI3

References