Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1071400..1072094 Replicon chromosome
Accession NZ_CP045258
Organism Yersinia pestis strain SCPM-O-B-5942 (I-2638)

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag GD372_RS04860 Protein ID WP_002214787.1
Coordinates 1071400..1071696 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag GD372_RS04865 Protein ID WP_002209924.1
Coordinates 1071696..1072094 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD372_RS04830 1066522..1068039 + 1518 WP_002209930.1 lysine--tRNA ligase -
GD372_RS04840 1068472..1069686 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
GD372_RS04845 1069768..1069953 - 186 WP_002209928.1 hypothetical protein -
GD372_RS04850 1070551..1070811 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
GD372_RS04855 1070874..1071236 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
GD372_RS04860 1071400..1071696 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
GD372_RS04865 1071696..1072094 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GD372_RS04870 1072486..1074777 - 2292 WP_002209923.1 toprim domain-containing protein -
GD372_RS04875 1075077..1075403 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
GD372_RS23070 1075396..1075548 + 153 WP_002209921.1 hypothetical protein -
GD372_RS04880 1075562..1075762 - 201 WP_002209920.1 AlpA family transcriptional regulator -
GD372_RS04885 1075944..1076276 - 333 WP_002214791.1 hypothetical protein -
GD372_RS04890 1076282..1076518 - 237 WP_002214792.1 hypothetical protein -
GD372_RS04895 1076531..1076896 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T141566 WP_002214787.1 NZ_CP045258:1071400-1071696 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T141566 NZ_CP060015:c2264610-2264335 [Mycobacterium malmoense]
ATGAGCATCAGCGCAAGCGAGGCTAGACAACGCCTGTACCCGCTTCTCGCGCAAGTCAATACCGATCACCAACCTGTGCG
CATCACCTCCAAAGCCGGCGACGCGGTGCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAAACGGTCTACCTGCTGC
GCTCACCAAAGAATGCCCAACGACTCATGGAAGCGGTCGCCCGGGACAAGGCCGGGCACTTTGCACTCACCAAGTCCGTC
GACGAGCTGCAGGAGATGGCCGGCGGCCAGGAGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT141566 WP_002209924.1 NZ_CP045258:1071696-1072094 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT141566 NZ_CP060015:c2264338-2264081 [Mycobacterium malmoense]
GTGAGAAGCATCCACTTCGATCCCAATGCCTGGGAGGACTTTCTATTCTGGCTGGGCTCCGACCGCAAGGCGGCCCGTCG
GGTCACCCGCCTGATCGCCGAGGTCCAACGCGATCCTTTCCGTGGCACCGGCAAACCCGAACCACTCAAGGGCGAGCTAT
CGGGTTACTGGTCCCGTCGAATCGACGACCAACATCGGCTTGTGTACCGAGCCGATGGCGACGAAGTCAAAATCCTCAAG
GCCCGATACCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References