Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2501112..2501769 Replicon chromosome
Accession NZ_CP045236
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BURCE16_RS28265 Protein ID WP_153490775.1
Coordinates 2501437..2501769 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BURCE16_RS28260 Protein ID WP_153490247.1
Coordinates 2501112..2501444 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS28245 2498591..2498980 + 390 WP_021160613.1 fucose-binding lectin II -
BURCE16_RS28250 2499105..2499926 + 822 WP_060341712.1 fucose-binding lectin II -
BURCE16_RS28255 2500080..2500925 + 846 WP_153490246.1 AraC family transcriptional regulator -
BURCE16_RS28260 2501112..2501444 - 333 WP_153490247.1 helix-turn-helix domain-containing protein Antitoxin
BURCE16_RS28265 2501437..2501769 - 333 WP_153490775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BURCE16_RS28270 2502059..2503423 - 1365 WP_153490249.1 M23 family metallopeptidase -
BURCE16_RS28275 2503764..2504633 + 870 WP_111938558.1 mechanosensitive ion channel family protein -
BURCE16_RS28280 2504714..2505856 - 1143 WP_111938559.1 branched-chain amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-102)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12900.03 Da        Isoelectric Point: 9.9627

>T141546 WP_153490775.1 NZ_CP045236:c2501769-2501437 [Burkholderia cepacia]
MKKWTILYYDERVKRDVFALPKGILAGYLRLIEAMEEHGADLRMPYSRAMGEGLFELRPRGREGIGRVFYCIRVGDELVV
LHSFVKKTQETPNDELQIARRRMKEVRNNG

Download         Length: 333 bp

>T141546 NZ_CP060008:3776194-3776484 [Pseudomonas sp. B11D7D]
ATGCCTCATACCCTGATCCCATTCGACATGGCTGAGCTGCTCGACAGTGAAGAGGCAGTCAGCGAGTACCTGTCTCAAGT
CCTGGCCGACGGCGACACTGATGAACTGATCCGCGCGATCGGCCATGTGGCCAAAGCACGCGGCATGTCGCAGATAGCCA
AGGACTCTGGCCTGGGTCGTGCGAGTCTCTACAAGGCCCTCGCCCCCGGCGCGCAACCACGGTTCGATACCGTGATCAAG
GTCATGCATGCCCTGGGCATTGAACTGCACGCTACCCCGGCCCATACCTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11937.50 Da        Isoelectric Point: 8.0521

>AT141546 WP_153490247.1 NZ_CP045236:c2501444-2501112 [Burkholderia cepacia]
MAKARPAHTSEERYAPVRHTAEDTARLLTDPAIKAEYDALEEEFTALRALLDARKDAGLTQAQVAERMGTTTSAVSRLEA
SFSSEKHSPSLATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT141546 NZ_CP060008:3775898-3776191 [Pseudomonas sp. B11D7D]
ATGGCATACCTCATCCAGCAGACAAAGACCTTCGCCAGCTGGCACTCCGCCGTACGCGATCTCAAGGCCAAGGTTGCAAT
CGCGCGCCGTATTGATCGAGCCGCCGCGGGCAACCTGGGTGATGTGAAGTCTGTAGGTGATGGAGTGTCTGAAATGCGCA
TTGATGTAGGCGCTGGCTACCGCCTGTACTTCACCGTCCGTGGCGGCATAGTCATTGTTCTGTTGGTAGGCGGCGACAAG
AGCACACAACCTGCTGATATCCGGCAGGCCAAGAAACTGGCAAAGGAGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References