Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 945335..946034 Replicon chromosome
Accession NZ_CP045236
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name mqsR Uniprot ID U2G672
Locus tag BURCE16_RS21390 Protein ID WP_021158759.1
Coordinates 945738..946034 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A105X490
Locus tag BURCE16_RS21385 Protein ID WP_042974280.1
Coordinates 945335..945736 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS21365 940975..942327 - 1353 WP_048024623.1 LLM class flavin-dependent oxidoreductase -
BURCE16_RS21370 942335..943384 - 1050 WP_153489510.1 LLM class flavin-dependent oxidoreductase -
BURCE16_RS21375 943453..944400 - 948 WP_059683599.1 ABC transporter substrate-binding protein -
BURCE16_RS21380 944457..945017 - 561 WP_153489512.1 GNAT family N-acetyltransferase -
BURCE16_RS21385 945335..945736 - 402 WP_042974280.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BURCE16_RS21390 945738..946034 - 297 WP_021158759.1 type II toxin-antitoxin system MqsR family toxin Toxin
BURCE16_RS21395 946138..947178 - 1041 WP_059484890.1 succinylglutamate desuccinylase/aspartoacylase family protein -
BURCE16_RS21400 947433..947708 - 276 WP_021158762.1 hypothetical protein -
BURCE16_RS21405 947950..949500 - 1551 WP_060061720.1 sensor domain-containing diguanylate cyclase -
BURCE16_RS21410 949499..949873 + 375 WP_153489513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-46)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11193.01 Da        Isoelectric Point: 8.0535

>T141541 WP_021158759.1 NZ_CP045236:c946034-945738 [Burkholderia cepacia]
MEKRRPHCKLSLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T141541 NZ_CP060003:40254-40655 [Xanthomonas citri pv. citri]
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAGAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTAAGAGCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14591.86 Da        Isoelectric Point: 8.8343

>AT141541 WP_042974280.1 NZ_CP045236:c945736-945335 [Burkholderia cepacia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT141541 NZ_CP060003:39997-40257 [Xanthomonas citri pv. citri]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGTACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G672

Antitoxin

Source ID Structure
AlphaFold DB A0A105X490

References