Detailed information of TA system TA141523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1526474..1527123
• Replicon: chromosome
• Accession: NZ_CP045222
• Organism: Achromobacter xylosoxidans strain DN002

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GCD73_RS06950
• Protein ID: WP_152383088.1
• Coordinates: 1526474..1526812 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GCD73_RS06955
• Protein ID: WP_152383089.1
• Coordinates: 1526809..1527123 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCD73_RS06930	1522536..1523729	+	1194	WP_152383084.1	acetylornithine transaminase	-
GCD73_RS06935	1523849..1524874	+	1026	WP_152383085.1	IS110 family transposase	-
GCD73_RS06940	1525203..1525529	+	327	WP_152383086.1	hypothetical protein	-
GCD73_RS06945	1525581..1526210	+	630	WP_152383087.1	class I SAM-dependent methyltransferase	-
GCD73_RS06950	1526474..1526812	+	339	WP_152383088.1	toxin	Toxin
GCD73_RS06955	1526809..1527123	+	315	WP_152383089.1	transcriptional regulator	Antitoxin
GCD73_RS06960	1527400..1527822	-	423	WP_152385396.1	DNA mismatch endonuclease Vsr	-
GCD73_RS06965	1527863..1529011	-	1149	WP_152383090.1	DNA cytosine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1525581..1554688	29107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-101)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13042.09 Da
• Isoelectric Point: 10.1516

>T141523 WP_152383088.1 NZ_CP045222:1526474-1526812 [Achromobacter xylosoxidans]
MKALFIELPAFSRYRAEYLDDDAFLDLQHAMMKHPAAGDVIEGTGGLRKLRHGDPRRGKGKRSGLRVIYYWWDGGSQFWL
FTLFDKDEMKDLSARAKQALKGMLEHERKIRL

Nucleotide

• Length: 339 bp

>T141523 NZ_CP059999:c2549250-2548837 [Xanthomonas citri pv. citri]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12021.86 Da
• Isoelectric Point: 10.2511

>AT141523 WP_152383089.1 NZ_CP045222:1526809-1527123 [Achromobacter xylosoxidans]
MKKRDLYSEIAEGFEALAEAREGKRTLRTHKVELKPAPEVTAEDLLALRQRLKLSRQVFAHYLRTNPRTVENWEQGRAKP
NAQAALLIRLVEKFPDTVERLAEV

Nucleotide

• Length: 315 bp

>AT141523 NZ_CP059999:c2549470-2549237 [Xanthomonas citri pv. citri]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA