Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2975476..2975978 | Replicon | chromosome |
| Accession | NZ_CP045209 | ||
| Organism | Escherichia coli strain 4 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | GC226_RS14590 | Protein ID | WP_000767829.1 |
| Coordinates | 2975476..2975730 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | GC226_RS14595 | Protein ID | WP_001259255.1 |
| Coordinates | 2975727..2975978 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GC226_RS14560 (2970495) | 2970495..2970722 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| GC226_RS14565 (2970736) | 2970736..2971794 | - | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| GC226_RS14570 (2971969) | 2971969..2973327 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| GC226_RS14575 (2973317) | 2973317..2973379 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| GC226_RS14580 (2973594) | 2973594..2974523 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| GC226_RS14585 (2974569) | 2974569..2975393 | - | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| GC226_RS14590 (2975476) | 2975476..2975730 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| GC226_RS14595 (2975727) | 2975727..2975978 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| GC226_RS14600 (2976261) | 2976261..2976311 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| GC226_RS14605 (2976457) | 2976457..2977356 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| GC226_RS14610 (2977362) | 2977362..2978666 | + | 1305 | WP_001369878.1 | histidinol dehydrogenase | - |
| GC226_RS14615 (2978663) | 2978663..2979733 | + | 1071 | WP_000108962.1 | histidinol-phosphate transaminase | - |
| GC226_RS14620 (2979733) | 2979733..2980800 | + | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T141472 WP_000767829.1 NZ_CP045209:c2975730-2975476 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T141472 NZ_CP059962:c4499822-4499535 [Pectobacterium brasiliense]
ATGAGCTATAGCGTTAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCAGCAAAGTTACGGGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCGTCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGATAA
ATGAGCTATAGCGTTAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCAGCAAAGTTACGGGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCGTCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT141472 WP_001259255.1 NZ_CP045209:c2975978-2975727 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT141472 NZ_CP059962:c4500070-4499819 [Pectobacterium brasiliense]
ATGCCGAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAACTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
CGATGGCCTGCCTGTTGCTATCTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGCAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA
ATGCCGAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAACTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
CGATGGCCTGCCTGTTGCTATCTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGCAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|