Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4019989..4020247 Replicon chromosome
Accession NZ_CP045206
Organism Escherichia coli strain DE17

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag GBG22_RS19685 Protein ID WP_000809168.1
Coordinates 4020095..4020247 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4019989..4020046 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBG22_RS19665 4016260..4016607 - 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
GBG22_RS19670 4016604..4016984 - 381 WP_001171554.1 IS66 family insertion sequence hypothetical protein -
GBG22_RS19675 4017209..4018702 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
GBG22_RS19680 4018722..4019483 - 762 WP_001274823.1 hypothetical protein -
- 4019989..4020046 - 58 - - Antitoxin
GBG22_RS19685 4020095..4020247 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
GBG22_RS19690 4020352..4021482 - 1131 WP_001118464.1 molecular chaperone DnaJ -
GBG22_RS19695 4021571..4023487 - 1917 WP_000516135.1 molecular chaperone DnaK -
GBG22_RS19700 4023859..4024263 + 405 WP_000843687.1 DUF2541 family protein -
GBG22_RS19705 4024289..4025001 + 713 Protein_3857 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T141441 WP_000809168.1 NZ_CP045206:4020095-4020247 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T141441 NZ_CP059960:c2765329-2765126 [Pectobacterium brasiliense]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGCCTTGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACTGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 58 bp

>AT141441 NZ_CP045206:c4020046-4019989 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References