Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354806..355452 Replicon chromosome
Accession NZ_CP045193
Organism Klebsiella pneumoniae strain YML0508

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag F8E20_RS01620 Protein ID WP_016529833.1
Coordinates 354806..355153 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag F8E20_RS01625 Protein ID WP_002920557.1
Coordinates 355153..355452 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8E20_RS01610 350732..352165 + 1434 WP_002920564.1 glycogen synthase GlgA -
F8E20_RS01615 352183..354630 + 2448 WP_002920561.1 glycogen phosphorylase -
F8E20_RS01620 354806..355153 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8E20_RS01625 355153..355452 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
F8E20_RS01630 355515..357023 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
F8E20_RS01635 357228..357557 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
F8E20_RS01640 357608..358438 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
F8E20_RS01645 358488..359246 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T141394 WP_016529833.1 NZ_CP045193:354806-355153 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T141394 NZ_CP059957:876872-877147 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGATCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCGCGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCCCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT141394 WP_002920557.1 NZ_CP045193:355153-355452 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT141394 NZ_CP059957:877144-877506 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTATGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGCTACCCTGAATCATTTGGGGAACGACTGACTATTGCGGCTGCTGAGCGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References