Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 854722..855416 Replicon chromosome
Accession NZ_CP045163
Organism Yersinia pestis strain SCPM-O-B-6291 (C-25)

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag GCK68_RS03825 Protein ID WP_002214787.1
Coordinates 855120..855416 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag GCK68_RS03820 Protein ID WP_002209924.1
Coordinates 854722..855120 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK68_RS03790 849915..850280 + 366 WP_002209919.1 hypothetical protein -
GCK68_RS03795 850293..850529 + 237 WP_002214792.1 hypothetical protein -
GCK68_RS03800 850535..850867 + 333 WP_002214791.1 hypothetical protein -
GCK68_RS03805 851049..851249 + 201 WP_002209920.1 AlpA family transcriptional regulator -
GCK68_RS21845 851263..851415 - 153 WP_002209921.1 hypothetical protein -
GCK68_RS03810 851408..851734 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK68_RS03815 852034..854325 + 2292 WP_002209923.1 toprim domain-containing protein -
GCK68_RS03820 854722..855120 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GCK68_RS03825 855120..855416 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
GCK68_RS03830 855580..855942 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
GCK68_RS03835 856005..856265 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK68_RS03840 856863..857048 + 186 WP_002209928.1 hypothetical protein -
GCK68_RS03845 857130..858344 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
GCK68_RS03855 858777..860294 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T141344 WP_002214787.1 NZ_CP045163:c855416-855120 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T141344 NZ_CP059947:3530680-3531222 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT141344 WP_002209924.1 NZ_CP045163:c855120-854722 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT141344 NZ_CP059947:3530385-3530696 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References