Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3467277..3467971 Replicon chromosome
Accession NZ_CP045158
Organism Yersinia pestis subsp. pestis bv. Medievalis strain SCPM-O-B-6530

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag DJY80_RS16515 Protein ID WP_002214787.1
Coordinates 3467675..3467971 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag DJY80_RS16510 Protein ID WP_002209924.1
Coordinates 3467277..3467675 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJY80_RS16480 3462467..3462832 + 366 WP_002209919.1 hypothetical protein -
DJY80_RS16485 3462845..3463081 + 237 WP_002214792.1 hypothetical protein -
DJY80_RS16490 3463087..3463419 + 333 WP_002214791.1 hypothetical protein -
DJY80_RS16495 3463601..3463801 + 201 WP_002209920.1 AlpA family transcriptional regulator -
DJY80_RS22960 3463815..3463967 - 153 WP_002209921.1 hypothetical protein -
DJY80_RS16500 3463960..3464286 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
DJY80_RS16505 3464586..3466877 + 2292 WP_002209923.1 toprim domain-containing protein -
DJY80_RS16510 3467277..3467675 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
DJY80_RS16515 3467675..3467971 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
DJY80_RS16520 3468135..3468497 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
DJY80_RS16525 3468560..3468820 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
DJY80_RS16530 3469418..3469603 + 186 WP_002209928.1 hypothetical protein -
DJY80_RS16535 3469685..3470899 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
DJY80_RS16545 3471332..3472849 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T141341 WP_002214787.1 NZ_CP045158:c3467971-3467675 [Yersinia pestis subsp. pestis bv. Medievalis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T141341 NZ_CP059947:2652543-2652650 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT141341 WP_002209924.1 NZ_CP045158:c3467675-3467277 [Yersinia pestis subsp. pestis bv. Medievalis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT141341 NZ_CP059947:c2652490-2652429 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References