Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3774144..3774838 Replicon chromosome
Accession NZ_CP045154
Organism Yersinia pestis strain SCPM-O-B-5935 (I-1996)

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag GCK71_RS17905 Protein ID WP_002214787.1
Coordinates 3774542..3774838 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag GCK71_RS17900 Protein ID WP_002209924.1
Coordinates 3774144..3774542 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK71_RS17870 3769340..3769705 + 366 WP_002209919.1 hypothetical protein -
GCK71_RS17875 3769718..3769954 + 237 WP_002214792.1 hypothetical protein -
GCK71_RS17880 3769960..3770292 + 333 WP_002214791.1 hypothetical protein -
GCK71_RS17885 3770474..3770674 + 201 WP_002209920.1 AlpA family transcriptional regulator -
GCK71_RS22975 3770688..3770840 - 153 WP_002209921.1 hypothetical protein -
GCK71_RS17890 3770833..3771159 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK71_RS17895 3771459..3773750 + 2292 WP_002209923.1 toprim domain-containing protein -
GCK71_RS17900 3774144..3774542 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GCK71_RS17905 3774542..3774838 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
GCK71_RS17910 3775002..3775364 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
GCK71_RS17915 3775427..3775687 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK71_RS17920 3776285..3776470 + 186 WP_002209928.1 hypothetical protein -
GCK71_RS17925 3776552..3777766 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
GCK71_RS17935 3778199..3779716 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T141326 WP_002214787.1 NZ_CP045154:c3774838-3774542 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T141326 NZ_CP059929:4408038-4408141 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT141326 WP_002209924.1 NZ_CP045154:c3774542-3774144 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT141326 NZ_CP059929:c4408179-4407908 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGTTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References