Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3260924..3261618 Replicon chromosome
Accession NZ_CP045149
Organism Yersinia pestis strain SCPM-O-DNA-18 (I-3113)

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag GCK70_RS15540 Protein ID WP_002214787.1
Coordinates 3261322..3261618 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag GCK70_RS15535 Protein ID WP_002209924.1
Coordinates 3260924..3261322 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK70_RS15505 3256121..3256486 + 366 WP_002209919.1 hypothetical protein -
GCK70_RS15510 3256499..3256735 + 237 WP_002214792.1 hypothetical protein -
GCK70_RS15515 3256741..3257073 + 333 WP_002214791.1 hypothetical protein -
GCK70_RS15520 3257255..3257455 + 201 WP_002209920.1 AlpA family transcriptional regulator -
GCK70_RS22880 3257469..3257621 - 153 WP_002209921.1 hypothetical protein -
GCK70_RS15525 3257614..3257940 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK70_RS15530 3258240..3260531 + 2292 WP_002209923.1 toprim domain-containing protein -
GCK70_RS15535 3260924..3261322 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GCK70_RS15540 3261322..3261618 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
GCK70_RS15545 3261782..3262144 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
GCK70_RS15550 3262207..3262467 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCK70_RS15555 3263065..3263250 + 186 WP_002209928.1 hypothetical protein -
GCK70_RS15560 3263332..3264546 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
GCK70_RS15570 3264979..3266496 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3243097..3269516 26419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T141311 WP_002214787.1 NZ_CP045149:c3261618-3261322 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T141311 NZ_CP059929:459256-459363 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT141311 WP_002209924.1 NZ_CP045149:c3261322-3260924 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT141311 NZ_CP059929:c459209-459143 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References