Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2330..2970 Replicon plasmid pPCP
Accession NZ_CP045148
Organism Yersinia pestis strain SCPM-O-B-6899 (231)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GCK69_RS22715 Protein ID WP_002225538.1
Coordinates 2629..2970 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q9S1D9
Locus tag GCK69_RS22710 Protein ID WP_002213446.1
Coordinates 2330..2629 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK69_RS22700 657..962 + 306 WP_002221218.1 hypothetical protein -
GCK69_RS22705 1205..2143 + 939 WP_002218234.1 omptin family plasminogen activator Pla -
GCK69_RS22710 2330..2629 - 300 WP_002213446.1 XRE family transcriptional regulator Antitoxin
GCK69_RS22715 2629..2970 - 342 WP_002225538.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GCK69_RS22725 4237..5259 + 1023 WP_000255944.1 IS21-like element IS100 family transposase -
GCK69_RS22730 5256..6038 + 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
GCK69_RS22735 7075..7269 + 195 WP_002213433.1 Rop family plasmid primer RNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - pla 1..9610 9610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13288.22 Da        Isoelectric Point: 8.8337

>T141299 WP_002225538.1 NZ_CP045148:c2970-2629 [Yersinia pestis]
MVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAIVL
CAGDKSNDKRFYEKLVRIAEDEFTAHLNTLESK

Download         Length: 342 bp

>T141299 NZ_CP059917:c4620086-4619979 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11127.94 Da        Isoelectric Point: 5.8900

>AT141299 WP_002213446.1 NZ_CP045148:c2629-2330 [Yersinia pestis]
MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGRRVAFHV

Download         Length: 300 bp

>AT141299 NZ_CP059917:4620143-4620201 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A080J016

References