Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 295388..295999 Replicon chromosome
Accession NZ_CP045144
Organism Ancylobacter sp. TS-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GBB76_RS01435 Protein ID WP_152304707.1
Coordinates 295388..295669 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GBB76_RS01440 Protein ID WP_152301640.1
Coordinates 295688..295999 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBB76_RS01420 291021..292400 - 1380 WP_152301637.1 aspartate aminotransferase family protein -
GBB76_RS01425 292579..293982 + 1404 WP_152301638.1 glutamine synthetase family protein -
GBB76_RS01430 294081..295190 + 1110 WP_152301639.1 polyamine ABC transporter substrate-binding protein -
GBB76_RS01435 295388..295669 + 282 WP_152304707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GBB76_RS01440 295688..295999 + 312 WP_152301640.1 HigA family addiction module antidote protein Antitoxin
GBB76_RS01445 296029..296934 - 906 WP_152301641.1 lipid A biosynthesis lauroyl acyltransferase -
GBB76_RS01450 296967..297989 - 1023 WP_152301642.1 zinc-binding dehydrogenase -
GBB76_RS01455 298092..298844 - 753 WP_152301643.1 SDR family oxidoreductase -
GBB76_RS01460 298954..300234 - 1281 WP_152301644.1 beta-ketoacyl-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-95)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10512.04 Da        Isoelectric Point: 8.0495

>T141282 WP_152304707.1 NZ_CP045144:295388-295669 [Ancylobacter sp. TS-1]
MILSTRGRFVEAVIAGKVPKGFPADLLRPAERRLRAIDAAVALDDLRSPPGNRLEMLKGERSGQHSIRINDQWRICFRWT
DAGAEDVEIVDYH

Download         Length: 282 bp

>T141282 NZ_CP059917:1299006-1299308 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11541.28 Da        Isoelectric Point: 5.8786

>AT141282 WP_152301640.1 NZ_CP045144:295688-295999 [Ancylobacter sp. TS-1]
MAVRFARPMHPGEILREEYLVPLGMSAGKLAKALDLPRTRIERIVREEIGISTDTALRLGRFFSTTPNFWLNLQQAYEVE
TEGARLAEEIGQIAPYAPADRAA

Download         Length: 312 bp

>AT141282 NZ_CP059917:1299344-1299685 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References