Detailed information of TA system TA141277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-sprA1AS/-
• Location: 2628403..2628551
• Replicon: chromosome
• Accession: NZ_CP045137
• Organism: Staphylococcus haemolyticus strain VB5326

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: GA597_RS13230
• Protein ID: WP_011276560.1
• Coordinates: 2628403..2628498 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2628516..2628551 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA597_RS13200 (GA597_03665)	2624283..2624408	+	126	WP_031886468.1	hypothetical protein	-
GA597_RS13205 (GA597_03660)	2625016..2626186	-	1171	Protein_2569	IS256-like element IS256 family transposase	-
GA597_RS13210 (GA597_03655)	2626342..2626872	+	531	WP_011276845.1	N-acetyltransferase	-
GA597_RS13215 (GA597_03650)	2627112..2627495	+	384	WP_011276846.1	effector binding domain-containing protein	-
GA597_RS13220 (GA597_03645)	2627634..2627894	+	261	WP_011276847.1	hypothetical protein	-
GA597_RS13225	2628062..2628208	+	147	WP_000668388.1	hypothetical protein	-
GA597_RS13230 (GA597_03635)	2628403..2628498	+	96	WP_011276560.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2628516..2628551	+	36	-	-	Antitoxin
GA597_RS13235 (GA597_03630)	2628692..2629351	+	660	WP_152235064.1	nucleotidyltransferase	-
GA597_RS13240 (GA597_03625)	2629597..2630199	+	603	WP_011276850.1	hypothetical protein	-
GA597_RS13245 (GA597_03615)	2630559..2631404	-	846	WP_000733283.1	BlaZ family penicillin-hydrolyzing class A beta-lactamase PC1	-
GA597_RS13250 (GA597_03610)	2631511..2633268	+	1758	WP_011276042.1	beta-lactam sensor/signal transducer BlaR1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	blaZ	-	2621643..2631404	9761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3670.48 Da
• Isoelectric Point: 11.0582

>T141277 WP_011276560.1 NZ_CP045137:2628403-2628498 [Staphylococcus haemolyticus]
MLEIFVHITTTVISGCIIALFTHWLRNRKKK

Nucleotide

• Length: 96 bp

>T141277 NZ_CP059917:c296996-296619 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 36 bp

>AT141277 NZ_CP045137:2628516-2628551 [Staphylococcus haemolyticus]
TACAAAAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin