Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2929689..2930274 Replicon chromosome
Accession NZ_CP045135
Organism Acinetobacter indicus strain XG01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GA636_RS14115 Protein ID WP_160232585.1
Coordinates 2929954..2930274 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GA636_RS14110 Protein ID WP_005108769.1
Coordinates 2929689..2929961 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA636_RS14090 2925232..2926041 + 810 WP_016659852.1 cytochrome c biogenesis protein CcsA -
GA636_RS14095 2926273..2927004 - 732 WP_104489952.1 GntR family transcriptional regulator -
GA636_RS14100 2927108..2928396 + 1289 Protein_2718 SLC13 family permease -
GA636_RS14105 2928404..2929207 + 804 WP_104489951.1 amidohydrolase family protein -
GA636_RS14110 2929689..2929961 - 273 WP_005108769.1 helix-turn-helix domain-containing protein Antitoxin
GA636_RS14115 2929954..2930274 - 321 WP_160232585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GA636_RS15115 2930517..2930666 - 150 WP_171502368.1 hypothetical protein -
GA636_RS14120 2930733..2930915 - 183 Protein_2723 hypothetical protein -
GA636_RS14125 2931024..2931995 - 972 Protein_2724 IS30 family transposase -
GA636_RS14130 2932151..2932366 - 216 WP_000071892.1 cold-shock protein -
GA636_RS14135 2932822..2933745 + 924 WP_104470641.1 tRNA-dihydrouridine synthase -
GA636_RS14140 2933828..2934232 - 405 WP_104489455.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12193.05 Da        Isoelectric Point: 8.8648

>T141272 WP_160232585.1 NZ_CP045135:c2930274-2929954 [Acinetobacter indicus]
MLFIETSIFIKQIKELVSGEEYRQLQQDLLVQPDKGDLIKNGSGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T141272 NZ_CP059908:111139-111537 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10050.52 Da        Isoelectric Point: 8.6797

>AT141272 WP_005108769.1 NZ_CP045135:c2929961-2929689 [Acinetobacter indicus]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTALELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT141272 NZ_CP059908:110912-111139 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References