Detailed information of TA system TA141238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3043..3694
• Replicon: plasmid p2ATCC19606
• Accession: NZ_CP045109
• Organism: Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8YFZ1
• Locus tag: FQU82_RS00075
• Protein ID: WP_000269904.1
• Coordinates: 3043..3399 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FQU82_RS00080
• Protein ID: WP_001129974.1
• Coordinates: 3392..3694 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU82_RS00065	186..1121	+	936	WP_001292329.1	replication initiation protein RepM	-
FQU82_RS00070	1199..1717	+	519	WP_000839337.1	plasmid replication DNA-binding protein	-
FQU82_RS00075	3043..3399	+	357	WP_000269904.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQU82_RS00080	3392..3694	+	303	WP_001129974.1	XRE family transcriptional regulator	Antitoxin
FQU82_RS00085	3687..3896	+	210	WP_000069474.1	hypothetical protein	-
FQU82_RS00090	4071..4589	+	519	WP_000447196.1	sel1 repeat family protein	-
FQU82_RS00095	4628..5140	+	513	WP_001089573.1	SMI1/KNR4 family protein	-
FQU82_RS00100	5338..5766	+	429	WP_000105988.1	organic hydroperoxide resistance protein	-
FQU82_RS00105	5773..6204	+	432	WP_000042163.1	MarR family transcriptional regulator	-
FQU82_RS00110	6437..6664	-	228	WP_000555568.1	hypothetical protein	-
FQU82_RS00115	6894..7655	-	762	WP_000425105.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9540	9540

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-81)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13488.42 Da
• Isoelectric Point: 5.7104

>T141238 WP_000269904.1 NZ_CP045109:3043-3399 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T141238 NZ_CP059901:c158999-158673 [Mumia sp. ZJ1417]
GTGAACCGCGGCGAGCTGTGGGCGGTCGCCGGCGGCACGTACGCGTCAAAGCCACGACCAGTTCTGATCCTTCAAGAGGA
TCTCTTCGACGCCACGGAGTCGGTCACCGTCGTTCCGCTGACCACGGCGGTTGTCGACGCCCCGTTGATCCGCATTCCCG
TTCCGGCTACGCGCACGACGGGGATCGACCGGCCGAGCTTCGCCATGGTCGACAAGATCACGACCGTACGCCGCAGCAAC
GTCGGCGCGCGCATCGGACGACTCCCCACCTCGCTGCTGGTCGATATCGAACGAGCGGCCTTGCTGTTCCTCGGCCTCGC
GCGCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11150.97 Da
• Isoelectric Point: 7.3198

>AT141238 WP_001129974.1 NZ_CP045109:3392-3694 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT141238 NZ_CP059901:c159199-158996 [Mumia sp. ZJ1417]
ATGAGCGTTCGTGACCGTGTTGCCGAGCACCGCCGGCGCATGCGTGAGCGCGGATACCGGCCGATCCAGGTGTGGGTCCC
CGACGTGCGGACCGAGCAGTTCCGCGACGAGGCGCACCGCCAGGCCGCGGCCCTCGCACGTGCGGATCGTCGCGCCGACG
ACCAGGACTTCGTCGACGAGATCTCCGACAGTTGGGACGAGTGA

Structures

Toxin

• AlphaFold DB: N8YFZ1