Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 3043..3694 | Replicon | plasmid p2ATCC19606 |
Accession | NZ_CP045109 | ||
Organism | Acinetobacter baumannii strain ATCC 19606 |
Toxin (Protein)
Gene name | higB | Uniprot ID | N8YFZ1 |
Locus tag | FQU82_RS00075 | Protein ID | WP_000269904.1 |
Coordinates | 3043..3399 (+) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | FQU82_RS00080 | Protein ID | WP_001129974.1 |
Coordinates | 3392..3694 (+) | Length | 101 a.a. |
Genomic Context
Location: 186..1121 (936 bp)
Type: Others
Protein ID: WP_001292329.1
Type: Others
Protein ID: WP_001292329.1
Location: 1199..1717 (519 bp)
Type: Others
Protein ID: WP_000839337.1
Type: Others
Protein ID: WP_000839337.1
Location: 3043..3399 (357 bp)
Type: Toxin
Protein ID: WP_000269904.1
Type: Toxin
Protein ID: WP_000269904.1
Location: 3392..3694 (303 bp)
Type: Antitoxin
Protein ID: WP_001129974.1
Type: Antitoxin
Protein ID: WP_001129974.1
Location: 3687..3896 (210 bp)
Type: Others
Protein ID: WP_000069474.1
Type: Others
Protein ID: WP_000069474.1
Location: 4071..4589 (519 bp)
Type: Others
Protein ID: WP_000447196.1
Type: Others
Protein ID: WP_000447196.1
Location: 4628..5140 (513 bp)
Type: Others
Protein ID: WP_001089573.1
Type: Others
Protein ID: WP_001089573.1
Location: 5338..5766 (429 bp)
Type: Others
Protein ID: WP_000105988.1
Type: Others
Protein ID: WP_000105988.1
Location: 5773..6204 (432 bp)
Type: Others
Protein ID: WP_000042163.1
Type: Others
Protein ID: WP_000042163.1
Location: 6437..6664 (228 bp)
Type: Others
Protein ID: WP_000555568.1
Type: Others
Protein ID: WP_000555568.1
Location: 6894..7655 (762 bp)
Type: Others
Protein ID: WP_000425105.1
Type: Others
Protein ID: WP_000425105.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FQU82_RS00065 | 186..1121 | + | 936 | WP_001292329.1 | replication initiation protein RepM | - |
FQU82_RS00070 | 1199..1717 | + | 519 | WP_000839337.1 | plasmid replication DNA-binding protein | - |
FQU82_RS00075 | 3043..3399 | + | 357 | WP_000269904.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FQU82_RS00080 | 3392..3694 | + | 303 | WP_001129974.1 | XRE family transcriptional regulator | Antitoxin |
FQU82_RS00085 | 3687..3896 | + | 210 | WP_000069474.1 | hypothetical protein | - |
FQU82_RS00090 | 4071..4589 | + | 519 | WP_000447196.1 | sel1 repeat family protein | - |
FQU82_RS00095 | 4628..5140 | + | 513 | WP_001089573.1 | SMI1/KNR4 family protein | - |
FQU82_RS00100 | 5338..5766 | + | 429 | WP_000105988.1 | organic hydroperoxide resistance protein | - |
FQU82_RS00105 | 5773..6204 | + | 432 | WP_000042163.1 | MarR family transcriptional regulator | - |
FQU82_RS00110 | 6437..6664 | - | 228 | WP_000555568.1 | hypothetical protein | - |
FQU82_RS00115 | 6894..7655 | - | 762 | WP_000425105.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..9540 | 9540 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13488.42 Da Isoelectric Point: 5.7104
>T141238 WP_000269904.1 NZ_CP045109:3043-3399 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG
Download Length: 357 bp
>T141238 NZ_CP059901:c158999-158673 [Mumia sp. ZJ1417]
GTGAACCGCGGCGAGCTGTGGGCGGTCGCCGGCGGCACGTACGCGTCAAAGCCACGACCAGTTCTGATCCTTCAAGAGGA
TCTCTTCGACGCCACGGAGTCGGTCACCGTCGTTCCGCTGACCACGGCGGTTGTCGACGCCCCGTTGATCCGCATTCCCG
TTCCGGCTACGCGCACGACGGGGATCGACCGGCCGAGCTTCGCCATGGTCGACAAGATCACGACCGTACGCCGCAGCAAC
GTCGGCGCGCGCATCGGACGACTCCCCACCTCGCTGCTGGTCGATATCGAACGAGCGGCCTTGCTGTTCCTCGGCCTCGC
GCGCTGA
GTGAACCGCGGCGAGCTGTGGGCGGTCGCCGGCGGCACGTACGCGTCAAAGCCACGACCAGTTCTGATCCTTCAAGAGGA
TCTCTTCGACGCCACGGAGTCGGTCACCGTCGTTCCGCTGACCACGGCGGTTGTCGACGCCCCGTTGATCCGCATTCCCG
TTCCGGCTACGCGCACGACGGGGATCGACCGGCCGAGCTTCGCCATGGTCGACAAGATCACGACCGTACGCCGCAGCAAC
GTCGGCGCGCGCATCGGACGACTCCCCACCTCGCTGCTGGTCGATATCGAACGAGCGGCCTTGCTGTTCCTCGGCCTCGC
GCGCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11150.97 Da Isoelectric Point: 7.3198
>AT141238 WP_001129974.1 NZ_CP045109:3392-3694 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT141238 NZ_CP059901:c159199-158996 [Mumia sp. ZJ1417]
ATGAGCGTTCGTGACCGTGTTGCCGAGCACCGCCGGCGCATGCGTGAGCGCGGATACCGGCCGATCCAGGTGTGGGTCCC
CGACGTGCGGACCGAGCAGTTCCGCGACGAGGCGCACCGCCAGGCCGCGGCCCTCGCACGTGCGGATCGTCGCGCCGACG
ACCAGGACTTCGTCGACGAGATCTCCGACAGTTGGGACGAGTGA
ATGAGCGTTCGTGACCGTGTTGCCGAGCACCGCCGGCGCATGCGTGAGCGCGGATACCGGCCGATCCAGGTGTGGGTCCC
CGACGTGCGGACCGAGCAGTTCCGCGACGAGGCGCACCGCCAGGCCGCGGCCCTCGCACGTGCGGATCGTCGCGCCGACG
ACCAGGACTTCGTCGACGAGATCTCCGACAGTTGGGACGAGTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | N8YFZ1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |