Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3043..3694 Replicon plasmid p2ATCC19606
Accession NZ_CP045109
Organism Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag FQU82_RS00075 Protein ID WP_000269904.1
Coordinates 3043..3399 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FQU82_RS00080 Protein ID WP_001129974.1
Coordinates 3392..3694 (+) Length 101 a.a.

Genomic Context


FQU82_RS00065FQU82_RS00070FQU82_RS00075FQU82_RS00080FQU82_RS00085FQU82_RS00090FQU82_RS00095FQU82_RS00100FQU82_RS00105FQU82_RS00110FQU82_RS00115
Location: 186..1121 (936 bp)
Type: Others
Protein ID: WP_001292329.1
Location: 1199..1717 (519 bp)
Type: Others
Protein ID: WP_000839337.1
Location: 3043..3399 (357 bp)
Type: Toxin
Protein ID: WP_000269904.1
Location: 3392..3694 (303 bp)
Type: Antitoxin
Protein ID: WP_001129974.1
Location: 3687..3896 (210 bp)
Type: Others
Protein ID: WP_000069474.1
Location: 4071..4589 (519 bp)
Type: Others
Protein ID: WP_000447196.1
Location: 4628..5140 (513 bp)
Type: Others
Protein ID: WP_001089573.1
Location: 5338..5766 (429 bp)
Type: Others
Protein ID: WP_000105988.1
Location: 5773..6204 (432 bp)
Type: Others
Protein ID: WP_000042163.1
Location: 6437..6664 (228 bp)
Type: Others
Protein ID: WP_000555568.1
Location: 6894..7655 (762 bp)
Type: Others
Protein ID: WP_000425105.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FQU82_RS00065186..1121+936WP_001292329.1replication initiation protein RepM-
FQU82_RS000701199..1717+519WP_000839337.1plasmid replication DNA-binding protein-
FQU82_RS000753043..3399+357WP_000269904.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FQU82_RS000803392..3694+303WP_001129974.1XRE family transcriptional regulatorAntitoxin
FQU82_RS000853687..3896+210WP_000069474.1hypothetical protein-
FQU82_RS000904071..4589+519WP_000447196.1sel1 repeat family protein-
FQU82_RS000954628..5140+513WP_001089573.1SMI1/KNR4 family protein-
FQU82_RS001005338..5766+429WP_000105988.1organic hydroperoxide resistance protein-
FQU82_RS001055773..6204+432WP_000042163.1MarR family transcriptional regulator-
FQU82_RS001106437..6664-228WP_000555568.1hypothetical protein-
FQU82_RS001156894..7655-762WP_000425105.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..95409540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-105)

Antitoxin

(31-81)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T141238 WP_000269904.1 NZ_CP045109:3043-3399 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

>T141238 NZ_CP059901:c158999-158673 [Mumia sp. ZJ1417]
GTGAACCGCGGCGAGCTGTGGGCGGTCGCCGGCGGCACGTACGCGTCAAAGCCACGACCAGTTCTGATCCTTCAAGAGGA
TCTCTTCGACGCCACGGAGTCGGTCACCGTCGTTCCGCTGACCACGGCGGTTGTCGACGCCCCGTTGATCCGCATTCCCG
TTCCGGCTACGCGCACGACGGGGATCGACCGGCCGAGCTTCGCCATGGTCGACAAGATCACGACCGTACGCCGCAGCAAC
GTCGGCGCGCGCATCGGACGACTCCCCACCTCGCTGCTGGTCGATATCGAACGAGCGGCCTTGCTGTTCCTCGGCCTCGC
GCGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT141238 WP_001129974.1 NZ_CP045109:3392-3694 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT141238 NZ_CP059901:c159199-158996 [Mumia sp. ZJ1417]
ATGAGCGTTCGTGACCGTGTTGCCGAGCACCGCCGGCGCATGCGTGAGCGCGGATACCGGCCGATCCAGGTGTGGGTCCC
CGACGTGCGGACCGAGCAGTTCCGCGACGAGGCGCACCGCCAGGCCGCGGCCCTCGCACGTGCGGATCGTCGCGCCGACG
ACCAGGACTTCGTCGACGAGATCTCCGACAGTTGGGACGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBN8YFZ1


Antitoxin

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Source
ID
Structure
No matching records found

References