Detailed information of TA system TA141237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3099..3684
• Replicon: plasmid p1ATCC19606
• Accession: NZ_CP045108
• Organism: Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8ZPD7
• Locus tag: FQU82_RS00025
• Protein ID: WP_000897309.1
• Coordinates: 3364..3684 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FQU82_RS00020
• Protein ID: WP_000369782.1
• Coordinates: 3099..3371 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU82_RS00005	144..1094	+	951	WP_001208779.1	replication initiation protein RepM	-
FQU82_RS00010	1087..1662	+	576	WP_001096618.1	helix-turn-helix domain-containing protein	-
FQU82_RS00015	1682..1825	+	144	WP_001125246.1	hypothetical protein	-
FQU82_RS00020	3099..3371	-	273	WP_000369782.1	helix-turn-helix domain-containing protein	Antitoxin
FQU82_RS00025	3364..3684	-	321	WP_000897309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQU82_RS00030	3871..4068	-	198	WP_000476222.1	hypothetical protein	-
FQU82_RS00035	4135..4362	-	228	WP_000921865.1	hypothetical protein	-
FQU82_RS00040	4460..4675	-	216	WP_000071892.1	cold-shock protein	-
FQU82_RS00045	5002..5514	-	513	WP_000064854.1	hypothetical protein	-
FQU82_RS00050	5609..5968	-	360	WP_000360920.1	hypothetical protein	-
FQU82_RS00055	6077..6217	-	141	WP_001985218.1	hypothetical protein	-
FQU82_RS00060	6217..6588	-	372	WP_000504219.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..7655	7655

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12209.01 Da
• Isoelectric Point: 7.9835

>T141237 WP_000897309.1 NZ_CP045108:c3684-3364 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T141237 NZ_CP059900:c4166354-4165932 [Tomitella sp. HY172]
CTGATCGTGGACACGAGCGCGCTGCTCGCATTCTTCGACGCCTCCGAACCCGACCATGCCGCGGTGAGTGCGGCGCTCAC
CGCGGAGGCCGGTGCGCTGGTGGTGTCTCCGTTCGTCGTCGCCGAGCTGGACTATCTCGTCGCCGCCAGGATCGGCGTCG
ACGCGGAACTCGCGGTGCTGGACGAGCTGGCGCAGGGCGCATGGGACCTGCCGGAGTTCGGCGCGGCGGAGTTGGCCGAG
GCCCGCGCGGTGGTGCAGCGCTACCGCGACCAGGACATCGGCGTGGCGGACGCATCCAACGTCGTTCTCGCGGGGCGGTA
CGGCACCGACCGCATCGCCACGCTCGACCATCGGCACTTCTCGGTTCTGCACACGGACCGCGGCGGCGCGTTCACGCTGG
TGCCCGGCGACGCGGGCCGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10064.50 Da
• Isoelectric Point: 7.2045

>AT141237 WP_000369782.1 NZ_CP045108:c3371-3099 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPGLI

Nucleotide

• Length: 273 bp

>AT141237 NZ_CP059900:c4166582-4166367 [Tomitella sp. HY172]
ATGAAGAAGACGACGCTGTACCTTCCTGACGAGCTGAAGGCCGCCGTAGCCCGCAGCGCGGCGCGGGAGGGCGTGTCGGA
GGCGGAAGTGATCCGCCGGTCCATCGCCCGCAGCGTCGGGGGCGAGCGTCCGCGACCACGTGGCGGCCTGTTCCGCAGCG
GCAGCCCGATCGCGCGTGAGGCGGACGCCCACCTGGCCGGCTTCGGGGAGAGGTAG

Structures

Toxin

• AlphaFold DB: A0A855WJQ3