Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1454594..1455096 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F9W95_RS06500 Protein ID WP_107332237.1
Coordinates 1454594..1454848 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag F9W95_RS06505 Protein ID WP_039324900.1
Coordinates 1454845..1455096 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS06480 (F9W95_06505) 1449748..1451010 - 1263 WP_233970406.1 L-rhamnose isomerase -
F9W95_RS06485 (F9W95_06510) 1451007..1452497 - 1491 WP_233976976.1 rhamnulokinase -
F9W95_RS06490 (F9W95_06515) 1452834..1453673 + 840 WP_116156386.1 HTH-type transcriptional activator RhaS -
F9W95_RS06495 (F9W95_06520) 1453698..1454552 + 855 WP_040031929.1 helix-turn-helix domain-containing protein -
F9W95_RS06500 (F9W95_06525) 1454594..1454848 - 255 WP_107332237.1 Txe/YoeB family addiction module toxin Toxin
F9W95_RS06505 (F9W95_06530) 1454845..1455096 - 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
F9W95_RS06510 (F9W95_06535) 1455171..1456877 - 1707 WP_116586200.1 ABC transporter ATP-binding protein -
F9W95_RS06515 (F9W95_06540) 1456874..1457740 - 867 WP_103861530.1 ABC transporter permease -
F9W95_RS06520 (F9W95_06545) 1457733..1458692 - 960 WP_029367586.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10171.76 Da        Isoelectric Point: 8.8560

>T141207 WP_107332237.1 NZ_CP045097:c1454848-1454594 [Pectobacterium carotovorum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITGDAMMIAAC
RYHY

Download         Length: 255 bp

>T141207 NZ_CP059889:2029037-2029139 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT141207 WP_039324900.1 NZ_CP045097:c1455096-1454845 [Pectobacterium carotovorum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT141207 NZ_CP059889:c2029146-2029001 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References