Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 755443..756794 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag F9W95_RS03345 Protein ID WP_125232112.1
Coordinates 755754..756794 (+) Length 347 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag F9W95_RS03340 Protein ID WP_240004567.1
Coordinates 755443..755757 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS03315 (F9W95_03335) 751268..752302 + 1035 WP_130640049.1 putative FMN-dependent luciferase-like monooxygenase -
F9W95_RS03320 (F9W95_03340) 752299..753432 + 1134 WP_240004566.1 alkylhydroperoxidase domain protein -
F9W95_RS03325 (F9W95_03345) 753489..753998 - 510 WP_039542420.1 phenolic acid decarboxylase -
F9W95_RS03330 (F9W95_03350) 754101..754973 + 873 WP_125232114.1 LysR family transcriptional regulator -
F9W95_RS03335 (F9W95_03355) 755132..755458 + 327 WP_103943145.1 helix-turn-helix domain-containing protein -
F9W95_RS03340 (F9W95_03360) 755443..755757 + 315 WP_240004567.1 HipA N-terminal domain-containing protein Antitoxin
F9W95_RS03345 (F9W95_03365) 755754..756794 + 1041 WP_125232112.1 HipA domain-containing protein Toxin
F9W95_RS03350 (F9W95_03370) 756855..757478 - 624 WP_233976906.1 LysE family translocator -
F9W95_RS03355 (F9W95_03375) 757746..758501 + 756 WP_205538192.1 thiol:disulfide interchange protein DsbG -
F9W95_RS03360 (F9W95_03380) 758536..759441 - 906 WP_103158323.1 siderophore-interacting protein -
F9W95_RS03365 (F9W95_03385) 759699..759950 + 252 WP_039533012.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F9W95_RS03370 (F9W95_03390) 759947..760234 + 288 WP_119159036.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(57-307)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 347 a.a.        Molecular weight: 39562.56 Da        Isoelectric Point: 6.3862

>T141201 WP_125232112.1 NZ_CP045097:755754-756794 [Pectobacterium carotovorum]
MTTCRILLTPLTHEEEMATGYSRKGLKHLAGSIHASPDLRFTRQQFMHDLPQTQKGMSISGYQPKIQMVLQDRAFIVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPDQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIRADGRQYISYERLALFLSEHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSEKLTKKLLADFIKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI

Download         Length: 1041 bp

>T141201 NZ_CP059855:323642-324388 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11900.64 Da        Isoelectric Point: 7.1966

>AT141201 WP_240004567.1 NZ_CP045097:755443-755757 [Pectobacterium carotovorum]
VRRQVKVYLYGVHIGQLSQDDEGYLFEYKKFYIGPPLSLSLPLQTGTFRSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDEA

Download         Length: 315 bp

>AT141201 NZ_CP059855:324389-324559 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References