Detailed information of TA system TA141189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1002634..1003157
• Replicon: chromosome
• Accession: NZ_CP045086
• Organism: Staphylococcus pseudintermedius strain KCTC 43136

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GAN21_RS04705
• Protein ID: WP_015729746.1
• Coordinates: 1002891..1003157 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: GAN21_RS04700
• Protein ID: WP_015729747.1
• Coordinates: 1002634..1002891 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAN21_RS04685	998682..999470	+	789	WP_152162864.1	arylamine N-acetyltransferase	-
GAN21_RS04690	999782..1000276	-	495	WP_015729749.1	membrane protein	-
GAN21_RS04695	1000536..1002440	+	1905	WP_152162865.1	triacylglycerol lipase	-
GAN21_RS04700	1002634..1002891	+	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GAN21_RS04705	1002891..1003157	+	267	WP_015729746.1	Txe/YoeB family addiction module toxin	Toxin
GAN21_RS04710	1003518..1003619	-	102	WP_019169745.1	DUF2648 domain-containing protein	-
GAN21_RS04715	1003633..1005126	-	1494	WP_014612817.1	malate dehydrogenase (quinone)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10541.08 Da
• Isoelectric Point: 10.1602

>T141189 WP_015729746.1 NZ_CP045086:1002891-1003157 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T141189 NZ_CP059851:c2935465-2935199 [Sandaracinobacter sp. M6]
GTGATCATCGTCTTCTTCCCGACCGCCTGGACAGCCTATTGTCACTGGCAGGCAACGGACAGGCAGACCCTGGAACGTTT
GAACGCCCTGATCGAGGAATGTTGTCGTCACCCCTTCACCGGAACCGGAAAGCCGGAGCCTTTGAAAAACGAGCTGAAAG
GGTTCTGGTCCCGTCGCATCACACGCGAAGACCGGCTGGTCTATCGTGTAGCCGGGCAGGGCAAGGAGCAACGGCTGGAA
ATCGCGCAATGCCGTTTTCACTACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT141189 WP_015729747.1 NZ_CP045086:1002634-1002891 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT141189 NZ_CP059851:c2935716-2935462 [Sandaracinobacter sp. M6]
ATGCGAGCAATGCACTATTCCGATACGCGGGCGAACTTGAAAACCGTGATGGACCGGGTGGTCGATGACCATGAGCCTGT
CATCGTCACGCGCCGTAACGGGGAGCCGGTGGTGATCGTATCGCTGTCGGACTGGAACTCAATGGACGAGACTGCCTATC
TCTTGTCCACGCCGGCCAATGCGGCGGCGTTGCGCGAGGCGGTGGCCGGCTTGAACGCCGGGCTGGGTGTGGAACGCGAA
CTCATCAATCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69