Detailed information of TA system TA141185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 919584..920107
• Replicon: chromosome
• Accession: NZ_CP045084
• Organism: Staphylococcus pseudintermedius strain KCTC 43134

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GAN19_RS04485
• Protein ID: WP_015729746.1
• Coordinates: 919584..919850 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: GAN19_RS04490
• Protein ID: WP_015729747.1
• Coordinates: 919850..920107 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAN19_RS04475	917615..919108	+	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
GAN19_RS04480	919122..919223	+	102	WP_019169745.1	DUF2648 domain-containing protein	-
GAN19_RS04485	919584..919850	-	267	WP_015729746.1	Txe/YoeB family addiction module toxin	Toxin
GAN19_RS04490	919850..920107	-	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GAN19_RS04495	920301..922205	-	1905	WP_152162865.1	triacylglycerol lipase	-
GAN19_RS04500	922465..922959	+	495	WP_015729749.1	membrane protein	-
GAN19_RS04505	923271..924059	-	789	WP_152162864.1	arylamine N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10541.08 Da
• Isoelectric Point: 10.1602

>T141185 WP_015729746.1 NZ_CP045084:c919850-919584 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T141185 NZ_CP059851:2074410-2074697 [Sandaracinobacter sp. M6]
TTGACGACCTATAGGCTAACATTCCTGCGCGACGCGAAGAAAGAATGGGACAAACTCGATTCAAAAATCCGCAATCAGTT
CAGCAAGAAGTTGGCAGAGCGTCTTTCTAACCCCCGCATCCCCTCGGCGAAACTCGCTGGTATGCCAAATTGCTACAAGA
TCAAACTGCACTCCGCTGGCTACCGCTTGGTCTATCGCGTCGATGACGGACGAATCGTGGTGCAGGTCATCGCCGTCGGC
AAACGCGAGCGAAGCGCTATTTACGAGGCAGCTAACAAGCGAATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT141185 WP_015729747.1 NZ_CP045084:c920107-919850 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT141185 NZ_CP059851:2074175-2074423 [Sandaracinobacter sp. M6]
ATGATCGAACCCCTCCTCGCGTCCGCCGCTGTCTCTATCAGCAACCTCAAGAAAAACCCCTCGGCCGTCATCGCTGCAGC
CGAAGGCGCGCCGGTCGCCATCCTCAACCGCAACACGCCGCAAGCCTACCTCGTGCCCGCCGCCGCATGGGAAGCCCTGA
TGGACCAGCTCGAAGACCTCGAACTCGCCGCCATCGTCCGCGAGCGCGAGGGCCAGGAAGAAATCGAGGTATCGATTGAC
GACCTATAG

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69