Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 2697547..2698081 Replicon chromosome
Accession NZ_CP045045
Organism Enterococcus faecalis strain JY32

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag F9293_RS12820 Protein ID WP_002360769.1
Coordinates 2697547..2697822 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag F9293_RS12825 Protein ID WP_002369771.1
Coordinates 2697815..2698081 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9293_RS12790 2692719..2692904 - 186 WP_002358660.1 hypothetical protein -
F9293_RS12795 2692934..2693263 + 330 WP_002358661.1 LPXTG cell wall anchor domain-containing protein -
F9293_RS12800 2693391..2694329 + 939 WP_002370935.1 2-dehydropantoate 2-reductase -
F9293_RS12805 2694355..2695392 + 1038 WP_002355369.1 PTS sugar transporter subunit IIC -
F9293_RS12810 2695697..2696591 - 895 Protein_2526 IS256 family transposase -
F9293_RS12815 2696676..2697356 + 681 Protein_2527 IS6-like element IS1216 family transposase -
F9293_RS12820 2697547..2697822 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
F9293_RS12825 2697815..2698081 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F9293_RS12830 2698192..2698776 - 585 WP_002377949.1 thermonuclease family protein -
F9293_RS12835 2698800..2699216 - 417 WP_010710134.1 single-stranded DNA-binding protein -
F9293_RS12840 2699292..2699540 - 249 WP_002360773.1 DUF3850 domain-containing protein -
F9293_RS12845 2699553..2700053 - 501 WP_002360775.1 DnaJ domain-containing protein -
F9293_RS12850 2700086..2700352 - 267 WP_002377947.1 hypothetical protein -
F9293_RS12855 2700944..2701432 - 489 WP_010710133.1 hypothetical protein -
F9293_RS12860 2701438..2702223 - 786 WP_002360778.1 replication-relaxation family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - esp / cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2 / bsh 2654188..2717690 63502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T141138 WP_002360769.1 NZ_CP045045:c2697822-2697547 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T141138 NZ_CP059835:c5012437-5012330 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT141138 WP_002369771.1 NZ_CP045045:c2698081-2697815 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT141138 NZ_CP059835:5012490-5012551 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References