Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 291552..291888 Replicon chromosome
Accession NZ_CP045045
Organism Enterococcus faecalis strain JY32

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag F9293_RS01415 Protein ID WP_002396786.1
Coordinates 291745..291888 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 291552..291601 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9293_RS01410 286859..291550 + 4692 WP_002378865.1 WxL domain-containing protein -
- 291552..291601 - 50 - - Antitoxin
F9293_RS01415 291745..291888 - 144 WP_002396786.1 putative holin-like toxin Toxin
F9293_RS01420 292220..293836 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
F9293_RS01425 294521..295159 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
F9293_RS01430 295326..296318 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
F9293_RS01435 296457..296672 + 216 WP_002354768.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T141132 WP_002396786.1 NZ_CP045045:c291888-291745 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T141132 NZ_CP059835:3547522-3547695 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 50 bp

>AT141132 NZ_CP045045:c291601-291552 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References