Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1067588..1068120 Replicon chromosome
Accession NZ_CP045033
Organism Lactobacillus kefiranofaciens subsp. kefiranofaciens strain LKK75

Toxin (Protein)


Gene name yoeB Uniprot ID A0A656YA18
Locus tag LKK75_RS05450 Protein ID WP_013854119.1
Coordinates 1067588..1067857 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A656Y9W5
Locus tag LKK75_RS05455 Protein ID WP_013854120.1
Coordinates 1067854..1068120 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKK75_RS05425 1062594..1063223 - 630 WP_013854114.1 Crp/Fnr family transcriptional regulator -
LKK75_RS05430 1063242..1063793 - 552 WP_013854115.1 DNA-binding protein -
LKK75_RS05435 1063793..1064023 - 231 WP_013854116.1 cation transporter -
LKK75_RS05440 1064046..1065947 - 1902 WP_013854117.1 heavy metal translocating P-type ATPase -
LKK75_RS05445 1066065..1067402 - 1338 WP_025084196.1 MATE family efflux transporter -
LKK75_RS05450 1067588..1067857 - 270 WP_013854119.1 Txe/YoeB family addiction module toxin Toxin
LKK75_RS05455 1067854..1068120 - 267 WP_013854120.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LKK75_RS05460 1068371..1069234 - 864 WP_025084193.1 alpha/beta hydrolase -
LKK75_RS05465 1069231..1070400 - 1170 WP_013854123.1 pyridoxal phosphate-dependent aminotransferase -
LKK75_RS05470 1070406..1071299 - 894 WP_013854124.1 DUF3737 family protein -
LKK75_RS05475 1071358..1071675 - 318 WP_025084192.1 carboxymuconolactone decarboxylase family protein -
LKK75_RS05480 1071685..1072100 - 416 Protein_1037 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10617.35 Da        Isoelectric Point: 10.4670

>T141126 WP_013854119.1 NZ_CP045033:c1067857-1067588 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
MILKYHGRIKNSAKPDLKKIKRSNLKDNFQDIIDQLKKDPYKKNQGFEKLEPPILGKYSRRINIKHRVVYTVDDVNKIVS
IYSAWSHYE

Download         Length: 270 bp

>T141126 NZ_CP059835:1615018-1615296 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9984.05 Da        Isoelectric Point: 4.4857

>AT141126 WP_013854120.1 NZ_CP045033:c1068120-1067854 [Lactobacillus kefiranofaciens subsp. kefiranofaciens]
MDATIYTPTGARRNLFNLIKQVNKNHTPVNIESTKDKAESAVLISKSDWDAIQETLYLESNGVGEVVRKREKDNSGFTDI
DDINWDEL

Download         Length: 267 bp

>AT141126 NZ_CP059835:1614755-1615015 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656YA18

Antitoxin

Source ID Structure
AlphaFold DB A0A656Y9W5

References