Detailed information of TA system TA141095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3599829..3600644
• Replicon: chromosome
• Accession: NZ_CP045008
• Organism: Proteus terrae subsp. cibarius strain ZF2

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: F9282_RS16910
• Protein ID: WP_075673429.1
• Coordinates: 3600171..3600644 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: F9282_RS16905
• Protein ID: WP_075673430.1
• Coordinates: 3599829..3600164 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9282_RS16885	3595518..3596942	+	1425	WP_072069056.1	aspartate ammonia-lyase	-
F9282_RS16890	3597101..3598426	+	1326	WP_036934359.1	anaerobic C4-dicarboxylate transporter	-
F9282_RS16895	3598610..3599182	+	573	WP_075673431.1	transcriptional regulator	-
F9282_RS16905	3599829..3600164	+	336	WP_075673430.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
F9282_RS16910	3600171..3600644	+	474	WP_075673429.1	type II toxin-antitoxin system YhaV family toxin	Toxin
F9282_RS16915	3600955..3601602	+	648	WP_075673428.1	CPBP family intramembrane metalloprotease	-
F9282_RS16920	3601905..3602540	+	636	WP_156734149.1	DUF1449 family protein	-
F9282_RS16925	3602627..3604822	+	2196	WP_099659727.1	flotillin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-147)

Antitoxin

• PrlF antitoxin (15-109)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 18639.26 Da
• Isoelectric Point: 9.2715

>T141095 WP_075673429.1 NZ_CP045008:3600171-3600644 [Proteus terrae subsp. cibarius]
MDFPTDLNGWTIYAHPCFKQQYDELLQKVEALKKKYPEDYQKKADTKIFAHVLKSIVNITNDPRAPEFRLGNTLGEENKN
WSRIKLVNGRYRLFFRFSFKEKIIILAWINDNDTLRTYGNKTDAYRVFEKKLKKGHPPKNWNDLFSDCINEADCQDP

Nucleotide

• Length: 474 bp

>T141095 NZ_CP059772:483316-483657 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12312.67 Da
• Isoelectric Point: 4.2560

>AT141095 WP_075673430.1 NZ_CP045008:3599829-3600164 [Proteus terrae subsp. cibarius]
MLTHVCTDNIALEADSKITERHQTTIPASIREALHLSGGDRIHYKLLSTGDVLISRHSDGSEDPVMASFLNFLAQDITNH
PQTIQPLDISRGFELVEGMDINLDDDITDNE

Nucleotide

• Length: 336 bp

>AT141095 NZ_CP059772:483086-483316 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG