Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2444242..2444837 Replicon chromosome
Accession NZ_CP045008
Organism Proteus terrae subsp. cibarius strain ZF2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F9282_RS11700 Protein ID WP_156733604.1
Coordinates 2444559..2444837 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F9282_RS11695 Protein ID WP_156733602.1
Coordinates 2444242..2444559 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9282_RS11680 2440991..2441521 - 531 WP_088495242.1 flagella biosynthesis regulatory protein FliZ -
F9282_RS11685 2441580..2442302 - 723 WP_036912728.1 RNA polymerase sigma factor FliA -
F9282_RS11690 2442745..2443866 - 1122 WP_156733600.1 FliC/FljB family flagellin -
F9282_RS11695 2444242..2444559 - 318 WP_156733602.1 HigA family addiction module antidote protein Antitoxin
F9282_RS11700 2444559..2444837 - 279 WP_156733604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F9282_RS11705 2445064..2446146 - 1083 WP_156733606.1 FliC/FljB family flagellin -
F9282_RS11710 2446534..2447952 + 1419 WP_156733607.1 flagellar filament capping protein FliD -
F9282_RS11715 2447973..2448371 + 399 WP_023581844.1 flagellar export chaperone FliS -
F9282_RS11720 2448390..2448743 + 354 WP_088495238.1 flagella biosynthesis regulatory protein FliT -
F9282_RS11725 2448901..2449365 - 465 WP_156733609.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10815.32 Da        Isoelectric Point: 9.3592

>T141092 WP_156733604.1 NZ_CP045008:c2444837-2444559 [Proteus terrae subsp. cibarius]
MIKSFGHKGLKQLFEKGITSGVLAQDVERINDRLQAIDVAQNISELNRQIYKLHKLKGEREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

>T141092 NZ_CP059765:c281564-281292 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11565.27 Da        Isoelectric Point: 7.0104

>AT141092 WP_156733602.1 NZ_CP045008:c2444559-2444242 [Proteus terrae subsp. cibarius]
MKQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRLLTGKTALTPSLAIRIAAALGSTPEFWLRLQSIYDLRQLE
DQIDTSKIEVYGEVADLVDRQSYSS

Download         Length: 318 bp

>AT141092 NZ_CP059765:c281827-281564 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References