Detailed information of TA system TA141079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2276035..2276643
• Replicon: chromosome
• Accession: NZ_CP044975
• Organism: Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2)

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: F9Z45_RS10570
• Protein ID: WP_159605930.1
• Coordinates: 2276035..2276313 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: F9Z45_RS10575
• Protein ID: WP_159605932.1
• Coordinates: 2276332..2276643 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9Z45_RS10565	2271947..2275984	+	4038	WP_159605928.1	phosphoribosylformylglycinamidine synthase	-
F9Z45_RS10570	2276035..2276313	+	279	WP_159605930.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9Z45_RS10575	2276332..2276643	+	312	WP_159605932.1	HigA family addiction module antidote protein	Antitoxin
F9Z45_RS10580	2276667..2277641	+	975	WP_159605934.1	DUF808 domain-containing protein	-
F9Z45_RS10585	2277783..2279519	+	1737	WP_159605936.1	toll/interleukin-1 receptor domain-containing protein	-
F9Z45_RS10590	2279618..2280163	+	546	WP_159605938.1	hemerythrin domain-containing protein	-
F9Z45_RS10595	2280221..2280976	+	756	WP_159605940.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10082.54 Da
• Isoelectric Point: 8.0440

>T141079 WP_159605930.1 NZ_CP044975:2276035-2276313 [Hydrogenophaga sp. PBL-H3]
MIVSFADRATADLFSGKPVKAFANILSVAQRKLQQLDSAVTLDALKAPPGNRLEGLKGDRKGQHSIGINDQFRLCFVWAA
DGVRDVEIVDYH

Nucleotide

• Length: 279 bp

>T141079 NZ_CP059749:22407-22757 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11318.34 Da
• Isoelectric Point: 9.6223

>AT141079 WP_159605932.1 NZ_CP044975:2276332-2276643 [Hydrogenophaga sp. PBL-H3]
MAVVAPINGLRPIHPGEILREDYLLPLGMSANALAHALKVPASRINDIVLERRGVTVDTAMRLVRYFGGDVQSWMNLQTA
YEVKVAQKELAPRIAKEVLPMAA

Nucleotide

• Length: 312 bp

>AT141079 NZ_CP059749:22150-22413 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA