Detailed information of TA system TA141070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 14425..15082
• Replicon: plasmid PNCS014881 strain 14[5]12:i:-
• Accession: NZ_CP044962
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014881

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: E5O18_RS24985
• Protein ID: WP_000270043.1
• Coordinates: 14732..15082 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E5O18_RS24980
• Protein ID: WP_000124640.1
• Coordinates: 14425..14727 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O18_RS24930	10050..10478	+	429	WP_000591074.1	hypothetical protein	-
E5O18_RS24935	10535..10894	+	360	WP_000422768.1	hypothetical protein	-
E5O18_RS24940	10894..11340	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
E5O18_RS24945	11337..11855	+	519	WP_000210756.1	nitrite reductase	-
E5O18_RS24950	11855..12085	+	231	WP_000972663.1	hypothetical protein	-
E5O18_RS24955	12072..12929	+	858	WP_001167032.1	hypothetical protein	-
E5O18_RS24965	13160..13687	+	528	WP_001236377.1	thermonuclease family protein	-
E5O18_RS24970	13745..14017	+	273	WP_001043047.1	HU family DNA-binding protein	-
E5O18_RS24975	14105..14398	+	294	WP_001239997.1	chromosome segregation protein ParM	-
E5O18_RS24980	14425..14727	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
E5O18_RS24985	14732..15082	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5O18_RS24990	15245..15793	+	549	WP_001061574.1	transcriptional regulator	-
E5O18_RS25000	16134..16328	+	195	WP_000343597.1	hypothetical protein	-
E5O18_RS25005	16339..16710	+	372	WP_000516916.1	hypothetical protein	-
E5O18_RS25010	16703..17173	+	471	WP_001281821.1	hypothetical protein	-
E5O18_RS25015	17188..17523	-	336	WP_000683476.1	hypothetical protein	-
E5O18_RS25020	17620..18108	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
E5O18_RS25025	18111..18608	+	498	WP_000062185.1	hypothetical protein	-
E5O18_RS25035	18823..19527	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
E5O18_RS25040	19834..20013	+	180	Protein_32	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..126750	126750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-113)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T141070 WP_000270043.1 NZ_CP044962:c15082-14732 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T141070 NZ_CP059739:479889-480230 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT141070 WP_000124640.1 NZ_CP044962:c14727-14425 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT141070 NZ_CP059739:479659-479889 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9