Detailed information of TA system TA141062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 5144164..5144864
• Replicon: chromosome
• Accession: NZ_CP044546
• Organism: Pseudomonas sp. CFA

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: F7661_RS23105
• Protein ID: WP_023389615.1
• Coordinates: 5144568..5144864 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A2L1I9E4
• Locus tag: F7661_RS23100
• Protein ID: WP_019437852.1
• Coordinates: 5144164..5144565 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7661_RS23080	5139250..5140071	-	822	WP_104961117.1	transporter substrate-binding domain-containing protein	-
F7661_RS23085	5140147..5141076	-	930	WP_010954958.1	FAD-binding protein	-
F7661_RS23090	5141077..5141826	-	750	WP_003254232.1	electron transfer flavoprotein subunit beta/FixA family protein	-
F7661_RS23095	5142362..5144044	+	1683	WP_023389616.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
F7661_RS23100	5144164..5144565	-	402	WP_019437852.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
F7661_RS23105	5144568..5144864	-	297	WP_023389615.1	type II toxin-antitoxin system MqsR family toxin	Toxin
F7661_RS23110	5144959..5146284	-	1326	WP_190869586.1	MFS transporter	-
F7661_RS23115	5146357..5146836	-	480	WP_019437855.1	hypothetical protein	-
F7661_RS23120	5147005..5147481	-	477	WP_190869587.1	sigma-70 family RNA polymerase sigma factor	-
F7661_RS23125	5147695..5148873	+	1179	WP_064493133.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11165.97 Da
• Isoelectric Point: 8.8385

>T141062 WP_023389615.1 NZ_CP044546:c5144864-5144568 [Pseudomonas sp. CFA]
MEKRTPHCPLERVRALVGAGRISPTTASLRGAQALGMEYADMLEVITGLERRDFYKSMTSYADHRVWQDVYRPLTVKGYL
YLKLSVVDDALIVSFKEL

Nucleotide

• Length: 297 bp

>T141062 NZ_CP059738:538671-538853 [Pseudomonas sp. 29A]
ATGCGCAGTCGGGAAATGATCAGGATGATCGAAGACGATGGTTGGTATCTCGTGGCGGTGAAAGGCAGCCATCACCAATA
CAAGCATCCGCACAAGCCAGGAAGGGTGACGATCAAGCACCCTGATTCGGATCTGCCCAAGGGCACGATCAACAGCATTT
TGAAACAGGCGGGCTTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14818.86 Da
• Isoelectric Point: 4.6580

>AT141062 WP_019437852.1 NZ_CP044546:c5144565-5144164 [Pseudomonas sp. CFA]
MRCPICGGAELALDTQDMPYRYKGESTLIPDVTGDYCSVCGEAVLSHDEAMRVSDLMSAFNRQVNALDVDPDFIVSVRKK
FDLDQREAGEIFGGGVNAFSRYENGKTKPPVALIKLFKLLDRHPELFEEVRTA

Nucleotide

• Length: 402 bp

>AT141062 NZ_CP059738:538913-539314 [Pseudomonas sp. 29A]
ATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGACTACGGAGTGATCATCCCGGATGTCCCGGGTTGTTTCTC
CGCAGGCACTACGGTCGCTGAGGCGTTTGAAAATACTCAGGAGGCATTGGCGCTTCACTATGAGGGGTTGGTCGCCGACA
GCGCGCCGTTACCGCAAGTGCGGGACATTGATGCTCATCTCGATAACCCGGATTACGCGGGAGGGATCTGGGGCGTGGTC
GATTTTGATATCACCCCGTATTTCGGCAAGTCAGTGCGTTTTAACGCCACGCTGCCGGAGCAGTTGCTTGAGCGTATTGA
CCAGACAGTCCGCCGTGACCAGCGCTATCGATCCCGTTCCGGATTTCTCGCGGCGGCCGCCTTGCGCGAACTGTCGGTAT
AG

Structures

Antitoxin

• AlphaFold DB: A0A2L1I9E4