Detailed information of TA system TA141043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2072100..2072760
• Replicon: chromosome
• Accession: NZ_CP044527
• Organism: Klebsiella grimontii strain SS141

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EHW69_RS10120
• Protein ID: WP_049099345.1
• Coordinates: 2072100..2072453 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A9E1DQ94
• Locus tag: EHW69_RS10125
• Protein ID: WP_004132739.1
• Coordinates: 2072458..2072760 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHW69_RS10095	2067484..2068251	-	768	WP_004132727.1	molybdopterin-dependent oxidoreductase	-
EHW69_RS10100	2068241..2068849	-	609	WP_004132729.1	cytochrome b/b6 domain-containing protein	-
EHW69_RS10105	2068864..2069490	-	627	WP_004132731.1	hypothetical protein	-
EHW69_RS10110	2069630..2070298	+	669	WP_004132733.1	heavy metal response regulator transcription factor	-
EHW69_RS10115	2070298..2071716	+	1419	WP_049085817.1	heavy metal sensor histidine kinase	-
EHW69_RS10120	2072100..2072453	+	354	WP_049099345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHW69_RS10125	2072458..2072760	+	303	WP_004132739.1	XRE family transcriptional regulator	Antitoxin
EHW69_RS10130	2072954..2073157	+	204	Protein_1960	hypothetical protein	-
EHW69_RS10135	2073158..2073491	+	334	Protein_1961	type II toxin-antitoxin system PemK/MazF family toxin	-
EHW69_RS10145	2073815..2075272	+	1458	WP_004136541.1	EmmdR/YeeO family multidrug/toxin efflux MATE transporter	-
EHW69_RS10155	2076300..2077754	-	1455	WP_024359975.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13616.61 Da
• Isoelectric Point: 9.5464

>T141043 WP_049099345.1 NZ_CP044527:2072100-2072453 [Klebsiella grimontii]
VWMIKTTDTFERWFISFNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Nucleotide

• Length: 354 bp

>T141043 NZ_CP059723:c2840658-2840551 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11072.83 Da
• Isoelectric Point: 5.7424

>AT141043 WP_004132739.1 NZ_CP044527:2072458-2072760 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Nucleotide

• Length: 303 bp

>AT141043 NZ_CP059723:2840706-2840772 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT