Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2251995..2252632 Replicon chromosome
Accession NZ_CP044522
Organism Cobetia sp. cqz5-12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F8A90_RS09515 Protein ID WP_200016831.1
Coordinates 2252339..2252632 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F8A90_RS09510 Protein ID WP_166018152.1
Coordinates 2251995..2252324 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8A90_RS09485 2247013..2247561 - 549 WP_200016826.1 hypothetical protein -
F8A90_RS09490 2248123..2248587 + 465 WP_200016827.1 carboxypeptidase regulatory-like domain-containing protein -
F8A90_RS09495 2248652..2249386 + 735 WP_200016828.1 AraC family transcriptional regulator -
F8A90_RS09500 2249577..2250704 + 1128 WP_200016829.1 DMT family transporter -
F8A90_RS09505 2250877..2251875 + 999 WP_200016830.1 EamA family transporter -
F8A90_RS09510 2251995..2252324 - 330 WP_166018152.1 HigA family addiction module antidote protein Antitoxin
F8A90_RS09515 2252339..2252632 - 294 WP_200016831.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8A90_RS09520 2252801..2254102 - 1302 WP_200016832.1 cytosine permease -
F8A90_RS09525 2254640..2257090 - 2451 WP_200016833.1 FdhF/YdeP family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11294.75 Da        Isoelectric Point: 7.3549

>T141040 WP_200016831.1 NZ_CP044522:c2252632-2252339 [Cobetia sp. cqz5-12]
MAVEFRDEWLESFYEQDVGHRKIPAALSSSLYRKLQILDAASQESDLRIPPGNRFEHLQGNLAGYCAIRVNRQYRLIFRW
EAGIAHQTYLDPHAYKG

Download         Length: 294 bp

>T141040 NZ_CP059723:c2137348-2136941 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12208.05 Da        Isoelectric Point: 7.4712

>AT141040 WP_166018152.1 NZ_CP044522:c2252324-2251995 [Cobetia sp. cqz5-12]
MRNTQRRPLTVGEMLAAEFLEPMDIDIRTLAEAMGVHRNTLSRIVHDKGTLTAPMAIKLAAALGNTPEFWLNIQHAVELW
DVRHRAYAQDAKGVRRITPQVDAAELASH

Download         Length: 330 bp

>AT141040 NZ_CP059723:c2137595-2137329 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References