Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5713..6406 Replicon plasmid p29FS20-1
Accession NZ_CP044520
Organism Acinetobacter baumannii strain 29FS20

Toxin (Protein)


Gene name higB Uniprot ID R9B971
Locus tag F7R60_RS19435 Protein ID WP_016165531.1
Coordinates 6116..6406 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6N0LK42
Locus tag F7R60_RS19430 Protein ID WP_035268402.1
Coordinates 5713..6114 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R60_RS19415 1402..2181 - 780 WP_150378261.1 ParA family protein -
F7R60_RS19420 3038..4210 + 1173 WP_150378260.1 replication initiation protein -
F7R60_RS19425 4366..5585 + 1220 WP_104425813.1 IS3 family transposase -
F7R60_RS19430 5713..6114 - 402 WP_035268402.1 helix-turn-helix domain-containing protein Antitoxin
F7R60_RS19435 6116..6406 - 291 WP_016165531.1 type II toxin-antitoxin system HigB family toxin Toxin
F7R60_RS19440 6572..6826 + 255 Protein_7 transposase -
F7R60_RS19445 6877..7422 - 546 WP_127800924.1 DNA-binding protein -
F7R60_RS19450 7528..8013 + 486 Protein_9 IS3 family transposase -
F7R60_RS19455 8063..8575 - 513 WP_150378258.1 signal peptidase II -
F7R60_RS19460 8579..9475 - 897 WP_150378257.1 cation transporter -
F7R60_RS19465 9571..9978 + 408 WP_001219642.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
F7R60_RS19470 10224..10877 - 654 Protein_13 IS5 family transposase -
F7R60_RS19475 11129..11350 - 222 WP_004658364.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aac(3)-IIa / blaTEM-2 / msr(E) / mph(E) / aph(3')-Ia / sul2 / aph(3'')-Ib / dfrA1 / floR / tet(X5) - 1..66277 66277
- inside IScluster/Tn - - 4366..10718 6352


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(19-90)

Antitoxin

Antitoxin HigA

(11-133)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11257.12 Da        Isoelectric Point: 10.1259

>T141038 WP_016165531.1 NZ_CP044520:c6406-6116 [Acinetobacter baumannii]
MHVITHARIIEAMHKWPQAETALDGWYRTIKANDPKDFAEMKQLFPAVDKVGKFHVFDIGGNKIRLIAVVMYQAKRVYIR
HVLSHKEYDKGHWKEG

Download         Length: 291 bp

>T141038 NZ_CP059723:c1003337-1003234 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14823.65 Da        Isoelectric Point: 4.3676

>AT141038 WP_035268402.1 NZ_CP044520:c6114-5713 [Acinetobacter baumannii]
MNAMIKQAVDHWHYVAPLLSKPENEDDFHTLVEALDELLDTVGDDESNPLMGLIHQLGDLVSDYENEHLPMPKGDGRAAL
AFLMEQHGLGQSDLAEVATQSVISEILSGKRQLNIRHIKALSERFNVSADTFF

Download         Length: 402 bp

>AT141038 NZ_CP059723:1003196-1003467 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9B971

Antitoxin

Source ID Structure
AlphaFold DB A0A6N0LK42

References